ID D4FSC2_STROR Unreviewed; 554 AA.
AC D4FSC2;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Chaperone protein DnaK {ECO:0000256|ARBA:ARBA00014415};
DE AltName: Full=Chaperone protein dnaK {ECO:0000256|ARBA:ARBA00017249};
DE AltName: Full=HSP70 {ECO:0000256|ARBA:ARBA00033103};
DE AltName: Full=Heat shock 70 kDa protein {ECO:0000256|ARBA:ARBA00030945};
DE AltName: Full=Heat shock protein 70 {ECO:0000256|ARBA:ARBA00030019};
GN Name=hscC {ECO:0000313|EMBL:EFE57093.1};
GN ORFNames=HMPREF8579_1053 {ECO:0000313|EMBL:EFE57093.1};
OS Streptococcus oralis ATCC 35037.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=655813 {ECO:0000313|EMBL:EFE57093.1, ECO:0000313|Proteomes:UP000001839};
RN [1] {ECO:0000313|EMBL:EFE57093.1, ECO:0000313|Proteomes:UP000001839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35037 {ECO:0000313|EMBL:EFE57093.1,
RC ECO:0000313|Proteomes:UP000001839};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a chaperone. {ECO:0000256|ARBA:ARBA00002290}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE57093.1}.
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DR EMBL; ADMV01000012; EFE57093.1; -; Genomic_DNA.
DR RefSeq; WP_000635029.1; NZ_LR134336.1.
DR AlphaFoldDB; D4FSC2; -.
DR GeneID; 49599545; -.
DR eggNOG; COG0443; Bacteria.
DR HOGENOM; CLU_005965_2_4_9; -.
DR Proteomes; UP000001839; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10235; HscC_like_NBD; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR042030; HscC_NBD.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR PANTHER; PTHR19375:SF184; STRESS-70 PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00012; HSP70; 2.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
SQ SEQUENCE 554 AA; 62581 MW; 12857861A2DF7752 CRC64;
MIVGIDLGTT NSLVGVYQDG QVKLIPNAFG EYLTPSVVAL DDNDEIIVGK IAKERLVTHP
DKTVSQFKRF MGTKHELTLG NRAYKAEELS SFIIRKLVDD AETYLGEKVE EVIVSVPAYF
NDAQRYATKL AGKFAGVQID RIINEPSAAA LAKRSVVNQE DQSFIVVDFG GGTLDISVVE
LFDNIVEIVS IAGDNRLGGE DFTSAIAEEF LVSNQLTKDS ISREFYSKIL VQAEKTKLEL
NSKEEVKMTV LDQDQEYTLD LSYQRFYELC QPLLARVKAV LDRALMDARY SYVSSDNFVL
VGGTSKLRLV QDFLSYCINQ VVQVSDDPDR MIARGCALLA GIKERQGEIR DLLLSDICPF
TLGIEIVGDR FSPIIERNST LPASRIEQYY TAELGQSQVK IKVYQGEMMK ASQNLFLGEL
EVPVPVNTRV NESFTVRFTY DLNGILDVEV KIDSTQEVFS HVILQDSVTL TEKEIKAKQA
ELTRYKINAQ ETEVYRFLIE KANRVYSMLL GRRRDELMAE TRRFEEEVSQ ASVYHLPKLY
QSFSNYLDFL ERGL
//
