ID D4FTE5_STROR Unreviewed; 297 AA.
AC D4FTE5;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 04-FEB-2015, entry version 22.
DE RecName: Full=tRNA pseudouridine synthase B {ECO:0000256|HAMAP-Rule:MF_01080};
DE EC=5.4.99.25 {ECO:0000256|HAMAP-Rule:MF_01080};
DE AltName: Full=tRNA pseudouridine(55) synthase {ECO:0000256|HAMAP-Rule:MF_01080};
DE AltName: Full=tRNA pseudouridylate synthase {ECO:0000256|HAMAP-Rule:MF_01080};
DE AltName: Full=tRNA-uridine isomerase {ECO:0000256|HAMAP-Rule:MF_01080};
GN Name=truB {ECO:0000256|HAMAP-Rule:MF_01080,
GN ECO:0000313|EMBL:EFE56400.1};
GN ORFNames=HMPREF8579_1426 {ECO:0000313|EMBL:EFE56400.1};
OS Streptococcus oralis ATCC 35037.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=655813 {ECO:0000313|EMBL:EFE56400.1};
RN [1] {ECO:0000313|EMBL:EFE56400.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 35037 {ECO:0000313|EMBL:EFE56400.1};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z.,
RA Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L.,
RA Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D.,
RA Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R.,
RA San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S.,
RA Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K.,
RA Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC 55 in the psi GC loop of transfer RNAs. {ECO:0000256|HAMAP-
CC Rule:MF_01080}.
CC -!- CATALYTIC ACTIVITY: tRNA uridine(55) = tRNA pseudouridine(55).
CC {ECO:0000256|HAMAP-Rule:MF_01080}.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC Type 1 subfamily. {ECO:0000256|HAMAP-Rule:MF_01080}.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:EFE56400.1}.
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DR EMBL; ADMV01000020; EFE56400.1; -; Genomic_DNA.
DR EnsemblBacteria; EFE56400; EFE56400; HMPREF8579_1426.
DR PATRIC; 36664321; VBIStrOra19579_1107.
DR OrthoDB; EOG6358D3; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR HAMAP; MF_01080; TruB_bact; 1.
DR InterPro; IPR002501; PsdUridine_synth.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR015225; tRNA_psdUridine_synth_fam2_C.
DR InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR PANTHER; PTHR13767; PTHR13767; 1.
DR Pfam; PF09142; TruB_C; 1.
DR Pfam; PF01509; TruB_N; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR TIGRFAMs; TIGR00431; TruB; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01080,
KW ECO:0000256|SAAS:SAAS00103062};
KW tRNA processing {ECO:0000256|HAMAP-Rule:MF_01080,
KW ECO:0000256|SAAS:SAAS00103090}.
FT ACT_SITE 43 43 Nucleophile. {ECO:0000256|HAMAP-Rule:
FT MF_01080}.
SQ SEQUENCE 297 AA; 32862 MW; B80F219992EE1EA7 CRC64;
MRKKHMNGII NLKKEAGMTS HDAVFKLRKI LGTKKIGHGG TLDPDVVGVL PIAVGKATRM
VEFMQDEGKV YEGEITLGYS TTTEDASGEV VAETPVLSPL DEKLVDEAIA SLTGPITQIP
PMYSAVKVNG RKLYEYARAG QEVERPERQV TIYQFERTSP ISYEDHLARF TFRVKCSKGT
YIRTLSVDLG EKLGYAAHMS HLTRTSAAGL QLEDALTLNE IAAKVEAGQL DFLHPLEIGT
GDLVKVFLTP EEATEVRFGR FIELDQTDKE LAAFEGDTLL AILEKRGNLY KPRKVFS
//
