ID D4GVH3_HALVD Unreviewed; 367 AA.
AC D4GVH3; L9UTX3;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=DUF21/CBS domain protein {ECO:0000313|EMBL:ADE02417.1};
GN OrderedLocusNames=HVO_0996 {ECO:0000313|EMBL:ADE02417.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE02417.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE02417.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001956; ADE02417.1; -; Genomic_DNA.
DR RefSeq; WP_004043947.1; NZ_AOHU01000092.1.
DR AlphaFoldDB; D4GVH3; -.
DR STRING; 309800.HVO_0996; -.
DR PaxDb; 309800-C498_13784; -.
DR EnsemblBacteria; ADE02417; ADE02417; HVO_0996.
DR GeneID; 8924840; -.
DR KEGG; hvo:HVO_0996; -.
DR PATRIC; fig|309800.29.peg.2650; -.
DR eggNOG; arCOG00626; Archaea.
DR HOGENOM; CLU_015237_4_0_2; -.
DR OrthoDB; 213548at2157; -.
DR Proteomes; UP000008243; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR43099:SF5; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..200
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 304..365
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 180..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 39131 MW; B572B24CA0D1A8C9 CRC64;
MVGVETALRL GGGLVLLLAN AFFVVSEFAM TRVPQFDESA FEGSRGLELA WEMTERLEVY
LSGCQVGITI ASVGLGVVAE PAVAATFDAV LGGGGAAGSH TSLSVGLALV VINLSHVVLG
EQVPTYLGVE RSRAVAKYTA PVLYGWTKLM YPVIVVADWL AKRLLSLVGV EITRSWQEAE
LDDEDGDGSA GEGTRLTRGE VRSQMGDVLS QGSLPEDRRE EVLNALRIGE LPVRDVMVPA
DHVVALSADA TTDESLERVR SNPQHSRFPL VGDSLDDVRG VVYAPTVLSN IDRLQSGDRR
LDDIAAPPLS VPSDLSVSDL IDRFQEENQE LAMVRDPESG SVVGLVTASD AFESITGQLY
DPLDLGA
//
