ID D4GY08_HALVD Unreviewed; 779 AA.
AC D4GY08; L9UHY9;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=DEAD/DEAH box helicase {ECO:0000313|EMBL:ADE02332.1};
DE EC=3.6.4.- {ECO:0000313|EMBL:ADE02332.1};
GN OrderedLocusNames=HVO_2955 {ECO:0000313|EMBL:ADE02332.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE02332.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE02332.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
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DR EMBL; CP001956; ADE02332.1; -; Genomic_DNA.
DR RefSeq; WP_004044810.1; NZ_AOHU01000104.1.
DR AlphaFoldDB; D4GY08; -.
DR STRING; 309800.HVO_2955; -.
DR PaxDb; 309800-C498_17935; -.
DR EnsemblBacteria; ADE02332; ADE02332; HVO_2955.
DR GeneID; 8924526; -.
DR KEGG; hvo:HVO_2955; -.
DR PATRIC; fig|309800.29.peg.3485; -.
DR eggNOG; arCOG00553; Archaea.
DR HOGENOM; CLU_006553_3_1_2; -.
DR OrthoDB; 371946at2157; -.
DR Proteomes; UP000008243; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF6; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ADE02332.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ADE02332.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243}.
FT DOMAIN 28..197
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 228..424
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 779 AA; 85818 MW; 116968C8415C8DB6 CRC64;
MKVAEAVPEF ADAFGFEEFN RMQREALPAI LDTDHNVVAS APTASGKTAL AELAICRTLR
DEGTALFIAP LRALTTEKET EWERFEDLGY SVYVVTGERD LNPRRAARAD ILVMTPEKTD
SATRKHDSAR YSFIEDVDCV VIDEVHLLDS ETRGGVLEVT VSRMRRICDP RIVALSATMP
NIDDVAAWLD APDETTFEFG DDYRPVDLHA GVKTYTHGEN SFADKYRRLY RAFDLAEPHI
RDGGQSLVFV SSRQDAVRAA AKARDELAKR DVPIGARGDY DFHNEAKELS NDSLAKGVLD
GVGFHHAGLS RDDREAVEEW FKEGKIQLLF STSTLAWGVN LPARCVVIRD TKHHDPLEGE
VDISPLDILQ MLGRAGRPGY DDVGYGWVVC DRSDQNKYRR LLREGKEIES RLAEDLDSHL
NAEIAMGTIR DLDDVMSWLE TTFYYRRAQS NPAAYDFEDL RSRVRDVLDR LVSRGFVEMD
DDLSIDATPL GRLTSKYYLR LGTASRFADL AERDRITADD VLETVAGAAD FRQVSARQSE
VDAVDSVLTG VSTTLEDGPK KVLAILHASM ANSTPSELRS DAWVIKQNAL RLLSALREFL
DTFADARAAN LAKRVEARVD NGVSSDAAAL TAVDGIGPGR ARKLATGGLS TPADVVDAGV
KELTRAGLSQ GVAERVIESA KDLPAPDIDW GEFPESVARG ESDMHDIRVR NDGGGGSVGV
RVTVNDVEMS TKTCYLSDEV TVPVGVFGAA DDELEFVVEV AFPDLPLLPI RESRTVRVE
//
