ID   D4HSR8_LEPIR            Unreviewed;       350 AA.
AC   D4HSR8;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   13-SEP-2023, entry version 22.
DE   SubName: Full=N-acylneuraminate-9-phosphate synthase {ECO:0000313|EMBL:ADC93951.1};
OS   Leptospira interrogans serovar Autumnalis.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=174157 {ECO:0000313|EMBL:ADC93951.1};
RN   [1] {ECO:0000313|EMBL:ADC93951.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Lin4 {ECO:0000313|EMBL:ADC93951.1};
RA   Cai C., Zhu Y., Zhong Y., Xin X., Jiang X.-G., He P., Qin J.-H.,
RA   Zhao G.-P., Guo X.-K.;
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADC93951.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Lin4 {ECO:0000313|EMBL:ADC93951.1};
RX   PubMed=20196873; DOI=10.1186/1471-2180-10-67;
RA   Cai C.S., Zhu Y.Z., Zhong Y., Xin X.F., Jiang X.G., Lou X.L., He P.,
RA   Qin J.H., Zhao G.P., Wang S.Y., Guo X.K.;
RT   "Development of O-antigen gene cluster-specific PCRs for rapid typing six
RT   epidemic serogroups of Leptospira in China.";
RL   BMC Microbiol. 10:67-67(2010).
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DR   EMBL; FJ976887; ADC93951.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4HSR8; -.
DR   GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR   CDD; cd11615; SAF_NeuB_like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR   InterPro; IPR006190; AFP_Neu5c_C.
DR   InterPro; IPR036732; AFP_Neu5c_C_sf.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013132; Neu5Ac_N.
DR   InterPro; IPR020030; Pseudaminic_synth_PseI.
DR   InterPro; IPR013974; SAF.
DR   NCBIfam; TIGR03586; PseI; 1.
DR   PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR   PANTHER; PTHR42966:SF2; PSEUDAMINIC ACID SYNTHASE; 1.
DR   Pfam; PF03102; NeuB; 1.
DR   Pfam; PF08666; SAF; 1.
DR   SMART; SM00858; SAF; 1.
DR   SUPFAM; SSF51269; AFP III-like domain; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50844; AFP_LIKE; 1.
PE   4: Predicted;
FT   DOMAIN          294..350
FT                   /note="AFP-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50844"
SQ   SEQUENCE   350 AA;  38804 MW;  37E25BE1326AFF80 CRC64;
     MNKINIGNQK IGNVFKPFII AEMSGNHNQS LEKALEIVDA AADAGAHAIK LQTYTADTIT
     IDKKEGEFFI SDPKSLWKGE SLYDLYKKAY TPWEWHESIF KRAKEKGIVC FSSPFDFTAV
     DFLESLNAPA YKIASFENID LPLIRKVANT GKPIIISTGM ANIQEIAEAV DTVRATGNNQ
     LILLKCTSTY PATPDNTNIL TIPHMRELFQ CEIGLSDHTL GIGVAVASVA LGATVIEKHF
     TLSRAEGGVD SAFSMEPVEM KSLVTETERA WQSLGKITYG PTEKERASMV FRRSLYVVED
     MNAGDKITER NVKSIRPGYG LPPKYLDVVV GKKLNRSLRM GTPLSWEFIE
//