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Database: UniProt
Entry: D4HY82_ERWAC
LinkDB: D4HY82_ERWAC
Original site: D4HY82_ERWAC 
ID   D4HY82_ERWAC            Unreviewed;       235 AA.
AC   D4HY82;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-SEP-2017, entry version 51.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=yfgE {ECO:0000313|EMBL:CBA21926.1};
GN   Synonyms=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN   OrderedLocusNames=EAMY_2538 {ECO:0000313|EMBL:CBA21926.1};
OS   Erwinia amylovora (strain CFBP1430).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=665029 {ECO:0000313|EMBL:CBA21926.1, ECO:0000313|Proteomes:UP000001841};
RN   [1] {ECO:0000313|EMBL:CBA21926.1, ECO:0000313|Proteomes:UP000001841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFBP1430 {ECO:0000313|Proteomes:UP000001841};
RX   PubMed=20192826; DOI=10.1094/MPMI-23-4-0384;
RA   Smits T.H., Rezzonico F., Kamber T., Blom J., Goesmann A., Frey J.E.,
RA   Duffy B.;
RT   "Complete genome sequence of the fire blight pathogen Erwinia
RT   amylovora CFBP 1430 and comparison to other Erwinia spp.";
RL   Mol. Plant Microbe Interact. 23:384-393(2010).
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
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DR   EMBL; FN434113; CBA21926.1; -; Genomic_DNA.
DR   RefSeq; WP_004159033.1; NC_013961.1.
DR   STRING; 665029.EAMY_2538; -.
DR   EnsemblBacteria; CBA21926; CBA21926; EAMY_2538.
DR   GeneID; 8911875; -.
DR   KEGG; eam:EAMY_2538; -.
DR   PATRIC; fig|665029.3.peg.2445; -.
DR   eggNOG; ENOG4108KZ1; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000256538; -.
DR   KO; K10763; -.
DR   OMA; DWGQIYR; -.
DR   Proteomes; UP000001841; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001841};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468}.
FT   DOMAIN       19    214       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   235 AA;  26652 MW;  0BAD7AB6E1A2D0D0 CRC64;
     MILNTPAQLS LPLYLPDDET FASFWPGENP LLLAALQSAL HQQHGSYFYF WSREGGGRSH
     LLHAACAELS AKGEAVGYVP LDKRTWFVPE VLDGMEQLAL VCIDNIECIA GDSPWEMAIF
     DLYNRILETG KTRLLITGDR PPRQLNLKLA DLASRLDWGQ IYKLQPLCDE DKLQALQLRA
     RLRGFELPED VGRFLLKRLD REMRTLFATL DQLDRASISA QRKLTIPFVK EALAL
//
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