ID D4I256_ERWAC Unreviewed; 282 AA.
AC D4I256;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN Name=yedU {ECO:0000313|EMBL:CBA23326.1};
GN OrderedLocusNames=EAMY_3249 {ECO:0000313|EMBL:CBA23326.1};
OS Erwinia amylovora (strain CFBP1430).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Erwinia.
OX NCBI_TaxID=665029 {ECO:0000313|EMBL:CBA23326.1, ECO:0000313|Proteomes:UP000001841};
RN [1] {ECO:0000313|EMBL:CBA23326.1, ECO:0000313|Proteomes:UP000001841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFBP1430 {ECO:0000313|Proteomes:UP000001841};
RX PubMed=20192826; DOI=10.1094/MPMI-23-4-0384;
RA Smits T.H., Rezzonico F., Kamber T., Blom J., Goesmann A., Frey J.E.,
RA Duffy B.;
RT "Complete genome sequence of the fire blight pathogen Erwinia amylovora
RT CFBP 1430 and comparison to other Erwinia spp.";
RL Mol. Plant Microbe Interact. 23:384-393(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN434113; CBA23326.1; -; Genomic_DNA.
DR RefSeq; WP_004160320.1; NC_013961.1.
DR AlphaFoldDB; D4I256; -.
DR STRING; 665029.EAMY_3249; -.
DR MEROPS; C56.006; -.
DR GeneID; 8913422; -.
DR KEGG; eam:EAMY_3249; -.
DR PATRIC; fig|665029.3.peg.3115; -.
DR eggNOG; COG0693; Bacteria.
DR HOGENOM; CLU_066933_0_0_6; -.
DR OrthoDB; 9792284at2; -.
DR Proteomes; UP000001841; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0036524; F:protein deglycase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR InterPro; IPR017283; HchA.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR PIRSF; PIRSF037798; Chaperone_HchA; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 75..192
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 282 AA; 30673 MW; 35BF559FF5C487A7 CRC64;
MSTELSKKPQ SDAAEHNAFF PSPYSLDQFT SRVSDLAGAD YPTSYRGNKK ILVIAADERY
LPVSGDKLFS TGNHPVETLL PMYHLHKAGF KCDIATLSGE MVKFEHWAMP VDDTIITGFF
ADYLADFRQP LKLSEVVKQL GADSDYAGVF IPGGHGALIG LPESEDVAAA IRWTLDQDNY
LISLCHGPAA FLSVSQGDNP LKGYSICAFP DSADKQTPDI GYMPGHLTWH FGERLKEMDL
TLVNDDISGA VHQDRKVLTG DSPFAANALG KLAANALLQA FS
//
