ID D4K5U4_9FIRM Unreviewed; 436 AA.
AC D4K5U4;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Mannose-1-phosphate guanylyltransferase {ECO:0000313|EMBL:CBL02953.1};
DE EC=5.3.1.8 {ECO:0000313|EMBL:CBL02953.1};
GN ORFNames=FPR_28540 {ECO:0000313|EMBL:CBL02953.1};
OS Faecalibacterium prausnitzii SL3/3.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Faecalibacterium.
OX NCBI_TaxID=657322 {ECO:0000313|EMBL:CBL02953.1, ECO:0000313|Proteomes:UP000007059};
RN [1] {ECO:0000313|EMBL:CBL02953.1, ECO:0000313|Proteomes:UP000007059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SL3/3 {ECO:0000313|EMBL:CBL02953.1,
RC ECO:0000313|Proteomes:UP000007059};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Faecalibacterium prausnitzii SL3/3.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL02953.1, ECO:0000313|Proteomes:UP000007059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SL3/3 {ECO:0000313|EMBL:CBL02953.1,
RC ECO:0000313|Proteomes:UP000007059};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FP929046; CBL02953.1; -; Genomic_DNA.
DR AlphaFoldDB; D4K5U4; -.
DR KEGG; fpa:FPR_28540; -.
DR PATRIC; fig|657322.3.peg.2722; -.
DR eggNOG; COG0662; Bacteria.
DR eggNOG; COG0836; Bacteria.
DR HOGENOM; CLU_035527_1_0_9; -.
DR Proteomes; UP000007059; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:RHEA.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005976; P:polysaccharide metabolic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:CBL02953.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000313|EMBL:CBL02953.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBL02953.1}.
FT DOMAIN 4..268
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 294..432
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 436 AA; 48569 MW; 661414B666DA50B9 CRC64;
MNVILLSGGS GKRLWPLSND VRSKQFIKLF KNNDEYESMV QRVYRQITTV DADAKITIAT
SKSQASAIKN QLGEKASICV EPCRRDTFPA IALAAAYLHD ELGVAENEAV VVCPVDPYVD
NTYYEAVKNL QELAEQGGAN LTLMGIEPTY PSEKYGYIIP ESGENVSKVK EFKEKPDVET
AKKYLAQSAL WNAGIFAFKL GYLLDKAHRM IDFEDYRDLF NKYDTLTKIS FDYAVVEKES
SIQVLRYSGD WKDVGTWNMM AEVMADKTKG KAVLDETCEN TNVVNELNIP ILCMGCKDMI
VAASGDGILI ADKERSGYMK PYVEKIETEA MYAEKSWGSY TVIDVQPGSM TVKISMRAGE
HMTYHMHNYR EEVWTVVSGK GKAVVDGMEQ VLRTGDVITI AAGCKHTVEA ITALGMIEVQ
LGDEISVADK IKFPMV
//
