ID   D4KKY3_9FIRM            Unreviewed;       771 AA.
AC   D4KKY3;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase {ECO:0000313|EMBL:CBL07535.1};
GN   ORFNames=ROI_02070 {ECO:0000313|EMBL:CBL07535.1};
OS   Roseburia intestinalis M50/1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=657315 {ECO:0000313|EMBL:CBL07535.1, ECO:0000313|Proteomes:UP000008807};
RN   [1] {ECO:0000313|EMBL:CBL07535.1, ECO:0000313|Proteomes:UP000008807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M50/1 {ECO:0000313|EMBL:CBL07535.1,
RC   ECO:0000313|Proteomes:UP000008807};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Roseburia intestinalis M50/1.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL07535.1, ECO:0000313|Proteomes:UP000008807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M50/1 {ECO:0000313|EMBL:CBL07535.1,
RC   ECO:0000313|Proteomes:UP000008807};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FP929049; CBL07535.1; -; Genomic_DNA.
DR   RefSeq; WP_006858885.1; NC_021040.1.
DR   AlphaFoldDB; D4KKY3; -.
DR   GeneID; 61431648; -.
DR   KEGG; rim:ROI_02070; -.
DR   PATRIC; fig|657315.3.peg.287; -.
DR   HOGENOM; CLU_012281_1_0_9; -.
DR   Proteomes; UP000008807; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 2.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR   PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 2.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CBL07535.1};
KW   Transferase {ECO:0000313|EMBL:CBL07535.1};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          594..771
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   COILED          516..546
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   771 AA;  88971 MW;  00020723AFE87653 CRC64;
     MELQNRKNLQ FRVSTALKSI IGKDLINDKY IAVFELVKNA YDAGAKRVDI IFENVNTLNS
     KLIIKDDGKG MDLPDIRDKW LFIAYSEKKK ENRKEVLNKN TDKKDYREHF KRETAGAKGV
     GRFSCDRLGA KVNLKSKTKD DENINCLCID WSKFEINDER EIKEVKVPYF TEQSDGFEQG
     TVLEICELRE PWKRADFLAL KRALMKLINP ENDLADDIFE IYLSVASELN ADRGVKRDNE
     KVNGKIKNDI IEKLGLKTTN IEVEISEDGQ TIKTELWDRG EFIFKFEEKN YKYIELKNIK
     FKLLYLNRSA KYNFSLVMGI TPVNYGSVMV YKNGFRIYPY GEPGEDLFYI DRRKSQGRNR
     YLGTRDIIGR ILILGENDEF METTSRDGGF VLNDTVNKFY DFFTRRVLRT LEKYVVDVID
     WGDPEKKDYE QGVEQGLLPR DVGDKILEQF AGYSSAKRKE LISFEYNKSL IEKMNEKKSD
     GIEASVQKLI SIANKTENEV LSELADKVKR DTYKILQQKR ETDVELENTQ DKLEAAHKEI
     NLRKQQNYFL EQAVNKNEKF LLSGMHLSLT YSEGAKGSML DLMDALRRKH ADDEEVQQYI
     SEIMINIQKI NKVSEYAIKG NFNLKSTEEE NDIRDFIIQY VGMSKYKGID IQFDSDTNEK
     YLCIFDVSSV GIIVDNIVSN AKKAAASILH IKFSNEENGI CINFSDNGRG LDPLIEDPYS
     IFDLGMTTTK VQGGNGIGLN HVKLLVEDMN GHVEINQQCQ VGFELIVRIK R
//