ID D4LFF6_RUMC1 Unreviewed; 309 AA.
AC D4LFF6;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Malonyl CoA-acyl carrier protein transacylase {ECO:0000256|PIRNR:PIRNR000446};
DE EC=2.3.1.39 {ECO:0000256|PIRNR:PIRNR000446};
GN OrderedLocusNames=RUM_23600 {ECO:0000313|EMBL:CBL18351.1};
OS Ruminococcus champanellensis (strain DSM 18848 / JCM 17042 / KCTC 15320 /
OS 18P13).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=213810 {ECO:0000313|EMBL:CBL18351.1, ECO:0000313|Proteomes:UP000007054};
RN [1] {ECO:0000313|EMBL:CBL18351.1, ECO:0000313|Proteomes:UP000007054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18848 / JCM 17042 / 18P13
RC {ECO:0000313|Proteomes:UP000007054};
RA Pajon A., Turner K., Parkhill J., Bernalier A.;
RT "The genome sequence of Ruminococcus sp. 18P13.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC Evidence={ECO:0000256|ARBA:ARBA00000936,
CC ECO:0000256|PIRNR:PIRNR000446};
CC -!- SIMILARITY: Belongs to the fabD family.
CC {ECO:0000256|PIRNR:PIRNR000446}.
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DR EMBL; FP929052; CBL18351.1; -; Genomic_DNA.
DR RefSeq; WP_015559257.1; NC_021039.1.
DR AlphaFoldDB; D4LFF6; -.
DR STRING; 213810.RUM_23600; -.
DR GeneID; 83157003; -.
DR KEGG; rch:RUM_23600; -.
DR PATRIC; fig|213810.4.peg.2251; -.
DR HOGENOM; CLU_030558_1_1_9; -.
DR BioCyc; RCHA213810:RUM_RS11480-MONOMER; -.
DR Proteomes; UP000007054; Chromosome.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR PANTHER; PTHR42681; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42681:SF1; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR PIRSF; PIRSF000446; Mct; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|PIRNR:PIRNR000446};
KW Reference proteome {ECO:0000313|Proteomes:UP000007054};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000446}.
FT DOMAIN 6..307
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
FT ACT_SITE 90
FT /evidence="ECO:0000256|PIRSR:PIRSR000446-1"
FT ACT_SITE 196
FT /evidence="ECO:0000256|PIRSR:PIRSR000446-1"
SQ SEQUENCE 309 AA; 32600 MW; 838F3C4020630658 CRC64;
MKNVLLFTGQ GSQFSGMGAA LAAMLPEASA IYEAGSDILG FDLKKMCLEG EDAVLAETCH
AQPAIYATEL ICLEALKARG IACEGVCGHS LGEYAAMTAC GMLTAENGFR ALKIRAQAMD
EAAKSQDSGM YAILRMPAER IGEICAQTPG YVVPVNFNSP AQTVIAGERQ AVDAAAKACA
AEKARAVPLA VAAAFHSKLM QPAADAIAAA FTAIPFAPPT VPFYTNLTGE PLAEGTDMAQ
YCAKHCVSPV RFAQELQNLH AAGFDTYIEL GPKKVLTSFV KQTLKDVDMH TVTDPDSLEE
TVTCLKHTD
//
