ID D4LWA4_9FIRM Unreviewed; 419 AA.
AC D4LWA4;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Tyrosine lyase ThiH {ECO:0000313|EMBL:CBL21907.1};
GN ORFNames=CK5_02840 {ECO:0000313|EMBL:CBL21907.1};
OS Blautia obeum A2-162.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX NCBI_TaxID=657314 {ECO:0000313|EMBL:CBL21907.1, ECO:0000313|Proteomes:UP000008955};
RN [1] {ECO:0000313|EMBL:CBL21907.1, ECO:0000313|Proteomes:UP000008955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A2-162 {ECO:0000313|EMBL:CBL21907.1,
RC ECO:0000313|Proteomes:UP000008955};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Ruminococcus obeum A2-162.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL21907.1, ECO:0000313|Proteomes:UP000008955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A2-162 {ECO:0000313|EMBL:CBL21907.1,
RC ECO:0000313|Proteomes:UP000008955};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FP929054; CBL21907.1; -; Genomic_DNA.
DR AlphaFoldDB; D4LWA4; -.
DR KEGG; rob:CK5_02840; -.
DR PATRIC; fig|657314.3.peg.993; -.
DR HOGENOM; CLU_046249_1_0_9; -.
DR Proteomes; UP000008955; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDG01081; cleavage_of_the_Ca-Cb_bond_in; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000313|EMBL:CBL21907.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 300..411
FT /note="Biotin and thiamin synthesis-associated"
FT /evidence="ECO:0000259|SMART:SM00876"
SQ SEQUENCE 419 AA; 48253 MW; 221CB73FFD0BC3C1 CRC64;
MNEENQVYFI DSDKLPPAAL KRKHRLEQDP SFRTNHMEYM EGMQVIESDI KDKVLHAMDT
YDYDAYTAGD VERALSHESC SIEDFKALLS PAAAPYLEQM ARKAEELTKN HFGNTVYIFT
PLYIANYCQN YCIYCGFNCY NNIRRKKLTF EEIEHEMQVI AKTGMEEILM LTGESRAYSD
VKYIGEAVKI ARKYFKNIGI EIYPVNVDEY QYLHECGVDY VTVFQETYNT DKYETLHLMG
HKRVWPYRFD AQERALMGGM RGAGFSALLG LDDFRKDALA TALHVYYINR KYPHAELSLS
CPRLRPIVNN DRINPRDVGE KELCQVLCAY RIFLPFAGIT VSSRESATFR NGIAKICATK
VSAGVSTGIG DHEEKYEGKE DDNVGDEQFE INDDRSFGKM YEDMEQGGLQ PVLNDYIYV
//
