ID D4M459_9FIRM Unreviewed; 1128 AA.
AC D4M459;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Diguanylate cyclase (GGDEF) domain {ECO:0000313|EMBL:CBL26021.1};
GN ORFNames=RTO_14010 {ECO:0000313|EMBL:CBL26021.1};
OS [Ruminococcus] torques L2-14.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Mediterraneibacter.
OX NCBI_TaxID=657313 {ECO:0000313|EMBL:CBL26021.1, ECO:0000313|Proteomes:UP000008956};
RN [1] {ECO:0000313|EMBL:CBL26021.1, ECO:0000313|Proteomes:UP000008956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-14 {ECO:0000313|EMBL:CBL26021.1,
RC ECO:0000313|Proteomes:UP000008956};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Ruminococcus torques L2-14.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL26021.1, ECO:0000313|Proteomes:UP000008956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-14 {ECO:0000313|EMBL:CBL26021.1,
RC ECO:0000313|Proteomes:UP000008956};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FP929055; CBL26021.1; -; Genomic_DNA.
DR AlphaFoldDB; D4M459; -.
DR STRING; 33039.ERS852502_01020; -.
DR KEGG; rto:RTO_14010; -.
DR PATRIC; fig|657313.3.peg.1203; -.
DR HOGENOM; CLU_279384_0_0_9; -.
DR Proteomes; UP000008956; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 2.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 2.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 2.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 2.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 415..552
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 729..863
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 872..1127
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1128 AA; 130701 MW; CD7B8B925E5D4A9D CRC64;
MKFKKKLWIS LILFILFGTV FSGWIFHQNT TREYLVFDNT TQLVTTERFE DNIRIEDVIL
PDSFQNQQSI LFKTTHTRAE VLLDGEKIYE FGNDTDTLRF MKSPGSCWHI VDLPKNSDGK
HLQVRIIPVY SDYYGNSFHL FGGTKGDCTL KILSNSLCSL VLSCEILSLG IICLILCFSI
MRKNDKYSSD ESYMIFLNLG VFSLLITLWT LKQCGFLQFL IPDPRALYFI DYFTFFLFPV
PFNFILYDIC KSKYRKGAVH LSILYLCNMA AAVLLQCTGV IDIFRILPVT HLIMLVNVIY
TVILIRYESI KLQNEAARHF KYPMYLVMAF GVAELIAYYI QHFQQTSIFL PFGTMLFTLL
LVWIQVSRFY DHYLQKQKLV YLQKLADTDL LTDTMNRNAY EKKVNRLNVQ KDKLHTTGLI
LFDLDNLKII NDRFGHEKGD EALQLCSQCI KQFFPDKENL FRIGGDEFAY FYNKNKENNI
GDKIAQLNQT LESTEHTFNY PLSISSGYAC FLPEMDNTFK DLAKRSDLML YRIKRKRKLA
YTGSSELLTS NTLINAGTSA EEKQQEEIFS HTKNYQDFSL KELCNIIDLL SPSTDGFLYM
LDFRTDFFYI SPQALDRFCL PGNEFHNMTK ELKEFVYKKD YPLLKAELDN LLNTDRNTHN
MDYRWLDLDR EPVWINCRGY IIRDDQQEPI YLIGCINEIG NRQKADNITG LLGETSLEKY
FKDSVSTLNK GFLIHVGIDG FKMINENYGW DYGDYVLRET ASCILSCISD SQKVYKIASD
EFIILDTTSS DMTTASNLYD HICKHINQFI EENNFAAVFT ISAGILPLPD LSQTGYAELI
KRTDFSLTMA KQHGRNCCYI FQEEEYQNFL RIREITNELH SAVNHGFRGF SIIFQPVMDI
RQDKLTGAEV LIRFTSKKFG PISPAEFIPL LETSGLIIPT GRWFMREAIT ACRKIRMQIP
DFKVNINVSQ VQITKSDVIT DLISEMNASG LPPAAIAIEL TESILLEKNE KAQNFLKELK
QAGLQLALDD FGTGYSNFHY LSELHPDIVK IDRGFTSKAI TDKKKYYLLN QFSNMIHNLG
LKLCIEGIET EDELQKIKLL KPDYCQGFYW GRPCSYDEFR KYFVDVDR
//
