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Database: UniProt
Entry: D4MA05_9BACT
LinkDB: D4MA05_9BACT
Original site: D4MA05_9BACT 
ID   D4MA05_9BACT            Unreviewed;       319 AA.
AC   D4MA05;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=Malate/lactate dehydrogenases {ECO:0000313|EMBL:CBL28700.1};
DE            EC=1.1.1.27 {ECO:0000313|EMBL:CBL28700.1};
GN   ORFNames=SY1_18390 {ECO:0000313|EMBL:CBL28700.1};
OS   Fretibacterium fastidiosum.
OC   Bacteria; Synergistota; Synergistia; Synergistales; Aminobacteriaceae;
OC   Fretibacterium.
OX   NCBI_TaxID=651822 {ECO:0000313|EMBL:CBL28700.1, ECO:0000313|Proteomes:UP000008957};
RN   [1] {ECO:0000313|EMBL:CBL28700.1, ECO:0000313|Proteomes:UP000008957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SGP1 {ECO:0000313|EMBL:CBL28700.1,
RC   ECO:0000313|Proteomes:UP000008957};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Wade W., Vartoukian S.;
RT   "The genome sequence of Synergistetes sp. SGP1.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL28700.1, ECO:0000313|Proteomes:UP000008957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SGP1 {ECO:0000313|EMBL:CBL28700.1,
RC   ECO:0000313|Proteomes:UP000008957};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily.
CC       {ECO:0000256|RuleBase:RU003369}.
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DR   EMBL; FP929056; CBL28700.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4MA05; -.
DR   KEGG; sbr:SY1_18390; -.
DR   PATRIC; fig|651822.3.peg.1101; -.
DR   HOGENOM; CLU_045401_1_2_0; -.
DR   BioCyc; FFAS651822:G13GF-1113-MONOMER; -.
DR   Proteomes; UP000008957; Chromosome.
DR   GO; GO:0004459; F:L-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd05291; HicDH_like; 1.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF31; L-LACTATE DEHYDROGENASE; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|PIRSR:PIRSR000102-3};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003369,
KW   ECO:0000313|EMBL:CBL28700.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008957}.
FT   DOMAIN          8..148
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          151..316
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   ACT_SITE        181
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
FT   BINDING         12..17
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         37
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         124..126
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
SQ   SEQUENCE   319 AA;  34697 MW;  82359577FBB02CCB CRC64;
     MQGKKRTVGI IGIGHVGAHV AYSLAVQGIA DEIILVDRER KKADCEAQDV MDSVCYLPHR
     VEVRSGDFPD LKDCDVLVNS AGHIQLLATG NKSRLEEMDF TIRAVNGYVD RVMESGFDGV
     VINVTNPCDV VAWRFAELSG LPRGRVFGTG TGLDTARLRS ALARQTGVDH KSICAYVMGE
     HGASQMVPWS SVSFGGRPLA EWERTDERFR FDREAIRKEA RDAGWVVFSG KQCTEYGICS
     TAARMASVVL LDEKQILPVT TRLEGEYGES GIFIGVPAVV GAGGAEQVVE VPMSAEELAE
     FKGCCDDVRA NMAHALEVR
//
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