ID   D4MPC7_9FIRM            Unreviewed;       550 AA.
AC   D4MPC7;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE            EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE   AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN   ORFNames=CL3_03740 {ECO:0000313|EMBL:CBL35613.1};
OS   butyrate-producing bacterium SM4/1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=245012 {ECO:0000313|EMBL:CBL35613.1, ECO:0000313|Proteomes:UP000008959};
RN   [1] {ECO:0000313|EMBL:CBL35613.1, ECO:0000313|Proteomes:UP000008959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM4/1 {ECO:0000313|EMBL:CBL35613.1,
RC   ECO:0000313|Proteomes:UP000008959};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Clostridiales sp. SM4/1.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL35613.1, ECO:0000313|Proteomes:UP000008959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM4/1 {ECO:0000313|EMBL:CBL35613.1,
RC   ECO:0000313|Proteomes:UP000008959};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474; EC=3.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000926};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; FP929060; CBL35613.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4MPC7; -.
DR   KEGG; bprm:CL3_03740; -.
DR   PATRIC; fig|245012.3.peg.2855; -.
DR   HOGENOM; CLU_025243_1_0_9; -.
DR   BioCyc; BBAC245012:G1313-167-MONOMER; -.
DR   Proteomes; UP000008959; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR   Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR004097; DHHA2.
DR   InterPro; IPR038222; DHHA2_dom_sf.
DR   InterPro; IPR010766; DRTGG.
DR   InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR   PANTHER; PTHR12112; BNIP - RELATED; 1.
DR   PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02833; DHHA2; 1.
DR   Pfam; PF07085; DRTGG; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01131; DHHA2; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR   SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CBL35613.1};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008959}.
FT   DOMAIN          256..313
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   550 AA;  61391 MW;  A431581046DE52F7 CRC64;
     MSDSKKRRTI VIGHKNPDTD SICSAICYAN LKHILTGEEY TPARAGHVNS ETQYVLDYFG
     VEAPELIENV RTQVKDIEIR ETKGVDKNIS LKKAWNLMQD NTVVTIPAVT EDNTLEGLIT
     VGDITRSYMN VYDSSILSKA CTQYSNILET LEGALLVGDP EAYFDKGKVL VAAANPDMME
     YYIEKHDLVI LGNRYESQLC AIEMEADCII VCEGAGVSMT IKKLAQERGC TVLTTPYDTY
     TAARLINQSM PISYFMTKDN LITFGTEDFI DDIRDVMTNK RHRDFPILDR DGKYKGMISR
     RNLLGARGKN LILVDHNERS QAVEGMESAN VMEIIDHHRL GTVETMSPVF FRNQPLGCTA
     TIIYQMYNEN KVEIDRKIAG LLCSAILSDT LLFRSPTCTA VDKAAALELA EIAGVDAESL
     AKEMFEAGSK LKGKTDSEIF YQDFKRFTAG KLTFGVGQIT SLNVEELGKI KERLIEYIGE
     ARNEQKVDMM FFMMTNILEQ STELICDGQG AEQLAALAFH LKEGEKVVTL PGVVSRKKQL
     IPALMIATEQ
//