ID D4MY45_ANAHA Unreviewed; 552 AA.
AC D4MY45;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=2-hydroxyglutaryl-CoA dehydratase {ECO:0000313|EMBL:AQP39294.1, ECO:0000313|EMBL:CUM71858.1};
DE SubName: Full=CoA-substrate-specific enzyme activase, putative {ECO:0000313|EMBL:CBL37540.1};
GN Name=hgdC_3 {ECO:0000313|EMBL:CUP99861.1};
GN Synonyms=hgdC_1 {ECO:0000313|EMBL:CUM71858.1};
GN ORFNames=CL2_04700 {ECO:0000313|EMBL:CBL37540.1}, DO83_06570
GN {ECO:0000313|EMBL:AQP39294.1}, ERS852425_00205
GN {ECO:0000313|EMBL:CUM71858.1}, ERS852520_02765
GN {ECO:0000313|EMBL:CUP99861.1}, ERS852571_00174
GN {ECO:0000313|EMBL:CUM71967.1};
OS Anaerostipes hadrus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerostipes.
OX NCBI_TaxID=649756 {ECO:0000313|EMBL:CBL37540.1, ECO:0000313|Proteomes:UP000008960};
RN [1] {ECO:0000313|EMBL:CBL37540.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL37540.1,
RC ECO:0000313|Proteomes:UP000008960};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SSC/2.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL37540.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL37540.1,
RC ECO:0000313|Proteomes:UP000008960};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000095553, ECO:0000313|Proteomes:UP000095564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5608868 {ECO:0000313|EMBL:CUM71858.1,
RC ECO:0000313|Proteomes:UP000095598}, 2789STDY5834908
RC {ECO:0000313|EMBL:CUP99861.1, ECO:0000313|Proteomes:UP000095564}, and
RC 2789STDY5834959 {ECO:0000313|EMBL:CUM71967.1,
RC ECO:0000313|Proteomes:UP000095553};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AQP39294.1, ECO:0000313|Proteomes:UP000188159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BPB5 {ECO:0000313|EMBL:AQP39294.1,
RC ECO:0000313|Proteomes:UP000188159};
RX PubMed=27264309; DOI=10.1038/srep27572;
RA Zhang Q., Wu Y., Wang J., Wu G., Long W., Xue Z., Wang L., Zhang X.,
RA Pang X., Zhao Y., Zhao L., Zhang C.;
RT "Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced
RT colitis by a butyrate-producing bacterium.";
RL Sci. Rep. 6:27572-27572(2016).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP012098; AQP39294.1; -; Genomic_DNA.
DR EMBL; FP929061; CBL37540.1; -; Genomic_DNA.
DR EMBL; CYXT01000001; CUM71858.1; -; Genomic_DNA.
DR EMBL; CYXY01000001; CUM71967.1; -; Genomic_DNA.
DR EMBL; CZAU01000033; CUP99861.1; -; Genomic_DNA.
DR RefSeq; WP_008391811.1; NZ_LR699012.1.
DR STRING; 649756.ERS852387_01765; -.
DR GeneID; 15230631; -.
DR KEGG; bprl:CL2_04700; -.
DR PATRIC; fig|245018.3.peg.648; -.
DR OrthoDB; 9778513at2; -.
DR Proteomes; UP000008960; Chromosome.
DR Proteomes; UP000095553; Unassembled WGS sequence.
DR Proteomes; UP000095564; Unassembled WGS sequence.
DR Proteomes; UP000095598; Unassembled WGS sequence.
DR Proteomes; UP000188159; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.50.11890; -; 1.
DR Gene3D; 3.40.50.11900; -; 1.
DR InterPro; IPR002731; ATPase_BadF.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR008275; CoA_E_activase_dom.
DR InterPro; IPR010327; FldB/FldC_alpha/beta.
DR NCBIfam; TIGR00241; CoA_E_activ; 1.
DR PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR PANTHER; PTHR32329:SF2; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR Pfam; PF01869; BcrAD_BadFG; 1.
DR Pfam; PF06050; HGD-D; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 298..546
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
SQ SEQUENCE 552 AA; 60823 MW; 984CC6AC95ACBDDF CRC64;
MSKTYYVCKY TPIELLQAFG GECENLNQMP EGFDLADQIA HPNICGFGKA VLEAVMTGKV
KELVLVNCCD TIRSVYDILE DSGKLDFLYM IDMLHCDGEC SRERTVLQLK GLARAYGAYK
GSEFDQKKFV EAFKEPEKQK EPYISVLGAR MGNELYEMVK ESMPYSVEND TCVNNRSVGE
VKPPKTDDFN ELMEWYAAEL LGQTPCMRMM DNSGRKRLYN DPNLKGIIYH TVKFCDFYSF
EYAQVKQNIT VPLLKIESDY TVQSSGQLLT RLEAFAESMN MDNLESGEKK MGKGYFAGID
SGSTSTDVVI LNKDGEIVTG IILPTGAGAA MGAERALEEA LKQAKLQRED IDAMVTTGYG
RTAITDGDKS ITEITCHARG AHFLNPEVRT VIDIGGQDSK VIRLDENGAV ANFVMNDKCA
AGTGRFLEMM ARTMEMDLDQ MSEAGLTYKE DITISSMCTV FAESEVVSLI AQNKETDDIV
HGLNKAVASK TAALAKRVGG EERYMMTGGV SKNKGLVKTL EEKLGTTLVI SDKAQLCGAL
GAALFAMDMV QK
//
