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Database: UniProt
Entry: D4MZL5_ANAHA
LinkDB: D4MZL5_ANAHA
Original site: D4MZL5_ANAHA 
ID   D4MZL5_ANAHA            Unreviewed;       460 AA.
AC   D4MZL5;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   22-NOV-2017, entry version 46.
DE   RecName: Full=M18 family aminopeptidase {ECO:0000256|RuleBase:RU004387};
DE            EC=3.4.11.- {ECO:0000256|RuleBase:RU004387};
GN   Name=apeA {ECO:0000313|EMBL:CUM80281.1};
GN   ORFNames=CL2_10650 {ECO:0000313|EMBL:CBL38060.1}, DO83_13065
GN   {ECO:0000313|EMBL:AQP40420.1}, ERS852425_01110
GN   {ECO:0000313|EMBL:CUM86741.1}, ERS852520_00663
GN   {ECO:0000313|EMBL:CUP12700.1}, ERS852571_00665
GN   {ECO:0000313|EMBL:CUM80281.1};
OS   Anaerostipes hadrus.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae;
OC   Anaerostipes.
OX   NCBI_TaxID=649756 {ECO:0000313|EMBL:CBL38060.1, ECO:0000313|Proteomes:UP000008960};
RN   [1] {ECO:0000313|EMBL:CBL38060.1, ECO:0000313|Proteomes:UP000008960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSC/2 {ECO:0000313|EMBL:CBL38060.1,
RC   ECO:0000313|Proteomes:UP000008960};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Clostridiales sp. SSC/2.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL38060.1, ECO:0000313|Proteomes:UP000008960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSC/2 {ECO:0000313|EMBL:CBL38060.1,
RC   ECO:0000313|Proteomes:UP000008960};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000095553, ECO:0000313|Proteomes:UP000095564, ECO:0000313|Proteomes:UP000095598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2789STDY5608868 {ECO:0000313|EMBL:CUM86741.1,
RC   ECO:0000313|Proteomes:UP000095598}, 2789STDY5834908
RC   {ECO:0000313|EMBL:CUP12700.1, ECO:0000313|Proteomes:UP000095564}, and
RC   2789STDY5834959 {ECO:0000313|EMBL:CUM80281.1,
RC   ECO:0000313|Proteomes:UP000095553};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AQP40420.1, ECO:0000313|Proteomes:UP000188159}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BPB5 {ECO:0000313|EMBL:AQP40420.1,
RC   ECO:0000313|Proteomes:UP000188159};
RX   PubMed=27264309; DOI=10.1038/srep27572;
RA   Zhang Q., Wu Y., Wang J., Wu G., Long W., Xue Z., Wang L., Zhang X.,
RA   Pang X., Zhao Y., Zhao L., Zhang C.;
RT   "Accelerated dysbiosis of gut microbiota during aggravation of DSS-
RT   induced colitis by a butyrate-producing bacterium.";
RL   Sci. Rep. 6:27572-27572(2016).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU004387};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|RuleBase:RU004386}.
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DR   EMBL; CP012098; AQP40420.1; -; Genomic_DNA.
DR   EMBL; FP929061; CBL38060.1; -; Genomic_DNA.
DR   EMBL; CYXY01000003; CUM80281.1; -; Genomic_DNA.
DR   EMBL; CYXT01000006; CUM86741.1; -; Genomic_DNA.
DR   EMBL; CZAU01000004; CUP12700.1; -; Genomic_DNA.
DR   RefSeq; WP_008391512.1; NZ_CZAU01000004.1.
DR   MEROPS; M18.004; -.
DR   EnsemblBacteria; CBL38060; CBL38060; CL2_10650.
DR   GeneID; 34241160; -.
DR   KEGG; bprl:CL2_10650; -.
DR   PATRIC; fig|245018.3.peg.1304; -.
DR   eggNOG; ENOG4105DFM; Bacteria.
DR   eggNOG; COG1362; LUCA.
DR   Proteomes; UP000008960; Chromosome.
DR   Proteomes; UP000095553; Unassembled WGS sequence.
DR   Proteomes; UP000095564; Unassembled WGS sequence.
DR   Proteomes; UP000095598; Unassembled WGS sequence.
DR   Proteomes; UP000188159; Chromosome.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   PANTHER; PTHR28570; PTHR28570; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; SSF101821; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|RuleBase:RU004386,
KW   ECO:0000313|EMBL:CBL38060.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008960,
KW   ECO:0000313|Proteomes:UP000095553, ECO:0000313|Proteomes:UP000095564,
KW   ECO:0000313|Proteomes:UP000095598};
KW   Hydrolase {ECO:0000256|RuleBase:RU004386,
KW   ECO:0000313|EMBL:CBL38060.1};
KW   Metal-binding {ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008960};
KW   Zinc {ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   460 AA;  51101 MW;  029808318650B016 CRC64;
     MNRENAWTTY EEADIKALEG LCKEYKDFLS NGKTERECVA QSIELAKKAG YQDLEELIKN
     QTPLKAGNKV YRTWMEKTIA LFQIGEDAIE DGLNILGAHI DSPRLDLKQN PLYEDTEMAL
     LDTHYYGGVK KYQWVTLPMA LHGVVVKKDG TKVNICIGEK DEDPVVGITD LLIHLSGKQM
     QKKGNVIVEG EDLNVLIGSK PLKGEEKEAV KKQLLQLFDE EYGIEEEDFL SAEIEVVPAG
     KARDFGLDRS MIMSYGQDDR VCAYTSLAAM LNVEAPKRTS CCILVDKEEI GSVGATGMHS
     RFFENTVAEI LALTGDYNDL RLRRTLQNSY MLSSDVSAAF DPNYPSVMEK KNCAYFGKGL
     VLNKYTGARG KSGSNDANPE YIAQLRKIFD EAKVAFQTAE LGKVDEGGGG TIAYIPAAYS
     MNVIDCGVAV LSMHAPWEIT SKSDIYEVEK GYEAFLKNCR
//
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