ID D4N122_ANAHA Unreviewed; 642 AA.
AC D4N122;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:CBL38567.1};
DE EC=3.7.1.- {ECO:0000313|EMBL:CBL38567.1};
GN ORFNames=CL2_16390 {ECO:0000313|EMBL:CBL38567.1};
OS Anaerostipes hadrus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerostipes.
OX NCBI_TaxID=649756 {ECO:0000313|EMBL:CBL38567.1, ECO:0000313|Proteomes:UP000008960};
RN [1] {ECO:0000313|EMBL:CBL38567.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL38567.1,
RC ECO:0000313|Proteomes:UP000008960};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SSC/2.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL38567.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL38567.1,
RC ECO:0000313|Proteomes:UP000008960};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; FP929061; CBL38567.1; -; Genomic_DNA.
DR RefSeq; WP_008392046.1; NZ_WQRB01000032.1.
DR AlphaFoldDB; D4N122; -.
DR GeneID; 15231658; -.
DR KEGG; bprl:CL2_16390; -.
DR PATRIC; fig|245018.3.peg.1935; -.
DR OMA; PNTYHLE; -.
DR Proteomes; UP000008960; Chromosome.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CBL38567.1};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 7..136
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 220..354
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 441..596
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 642 AA; 70513 MW; EEC1CB419EAF691B CRC64;
MAKTVRMTVA QAIVKFLDNQ YVSMDGEETK FVEGFFTIFG HGIAVGLGEA LDTNPGNLRV
LQGRNEQGMC HVATAYAKQN GRKKIIPCAS SVGPGAANMV TACATATVNN IPLLVFPADT
FASRQPDPVL QQLEQSNSLS TTTNDAFKPV CKYWDRVTRP EHIMTALINA MRVLTDPAET
GACCIGLCQD VEGESFDFPE YFFEKRVHRI TRPVAVEEEI EDIANVIANA KKPLVIVGGG
VRYSEAGEEV EKFCEEFKIP FGETQGGKSA CRSSHPYCMG GIGVTGTYAS NVLAKDADVV
IAIGSRMSDF ATGSKRQFAN PDVKFVSINN SRYHAYKLDS VKAVGDAKVT VKALAEKLRA
MNYVSSYNGE IEEAKAVWDK EMKRLAEYKY DETFEPMIKN MDPRTIPEFV ELTKGKITQT
AALATIRDVI DEDATIITAG GSLPSCMQRV WTTDKRGGYH AEYGYSCMGY EVAAALGVKL
AEPDNEVYAV VGDASFQMLH SEIMTMMQEK QKANILVFDN CGFGCINNLQ MNHGIGSLAT
EFRYREGNKP CGDLIPVDYA KVAEGYGLKS YTCKTIEELR AALEDAKKQN VACLFDLKVI
PKTMTDGYES WWNVGIATTS EKESVRKACE GVMEGRKEAR AY
//