ID   D4P700_PANAN            Unreviewed;       796 AA.
AC   D4P700;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=PQQ-linked membrane-bound glucose dehydrogenase {ECO:0000313|EMBL:ADD81202.1};
DE            EC=1.1.5.2 {ECO:0000313|EMBL:ADD81202.1};
GN   Name=gcd {ECO:0000313|EMBL:ADD81202.1};
OS   Pantoea ananas (Erwinia uredovora).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea.
OX   NCBI_TaxID=553 {ECO:0000313|EMBL:ADD81202.1};
RN   [1] {ECO:0000313|EMBL:ADD81202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SC17 {ECO:0000313|EMBL:ADD81202.1};
RX   PubMed=21306430; DOI=10.1111/j.1574-6968.2011.02240.x;
RA   Andreeva I.G., Golubeva L.I., Kuvaeva T.M., Gak E.R., Katashkina J.I.,
RA   Mashko S.V.;
RT   "Identification of Pantoea ananatis gene encoding membrane pyrroloquinoline
RT   quinone (PQQ)-dependent glucose dehydrogenase and pqqABCDEF operon
RT   essential for PQQ biosynthesis.";
RL   FEMS Microbiol. Lett. 318:55-60(2011).
CC   -!- COFACTOR:
CC       Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI:58442;
CC         Evidence={ECO:0000256|ARBA:ARBA00001931};
CC   -!- SIMILARITY: Belongs to the bacterial PQQ dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00008156}.
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DR   EMBL; GU580893; ADD81202.1; -; Genomic_DNA.
DR   RefSeq; WP_014595091.1; NZ_VDNR01000010.1.
DR   AlphaFoldDB; D4P700; -.
DR   BRENDA; 1.1.5.2; 2137.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0008876; F:quinoprotein glucose dehydrogenase activity; IEA:UniProtKB-EC.
DR   CDD; cd10280; PQQ_mGDH; 1.
DR   Gene3D; 2.140.10.10; Quinoprotein alcohol dehydrogenase-like superfamily; 1.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR017511; PQQ_mDH.
DR   InterPro; IPR002372; PQQ_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR001479; Quinoprotein_DH_CS.
DR   NCBIfam; TIGR03074; PQQ_membr_DH; 1.
DR   PANTHER; PTHR32303; QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C); 1.
DR   PANTHER; PTHR32303:SF4; QUINOPROTEIN GLUCOSE DEHYDROGENASE; 1.
DR   Pfam; PF01011; PQQ; 4.
DR   Pfam; PF13360; PQQ_2; 1.
DR   SMART; SM00564; PQQ; 6.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS00364; BACTERIAL_PQQ_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ADD81202.1}; PQQ {ECO:0000256|ARBA:ARBA00022891};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        40..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        64..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        86..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        120..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          621..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   796 AA;  86319 MW;  8E860841F5DBDC2F CRC64;
     MGKNSSSFSV VRFLTVLFAV LTGAFMLIGG IWLATIGGSW YYIIGGAAML LTAFLLWRRN
     SAALVVYALL LLATLAWGVW EVGTDFWALA PRTDVLVIFG VWLVLPFVYR GLYQPGKGAL
     GAMGVALVAS AAVLTYSVFN DPQVVNGALP ATADNAPQAQ PLSNIADGDW PAYARDQQGT
     RFSPLKQINH DNVKELQVAW QFQTGDMKRP SDPGEITDEV TPIKIRDTLY LCTPHQILFA
     LDAATGKQKW KFDPGLKTNP TFQHVTCRGV SYHEFPAAKD ASNTQPALCS RRIYLPVNDG
     RLFALDAETG ERCPAFGNNG ELDLQHKQPV TTPGMYEPTS PPVITDTTIV MAGAVTDNFS
     TREPSGAIRG FDVNTGKLLW VFDPGAKDPN AIPADEHTFT MNSPNSWAPA VYDPKLDIVY
     LPMGVTTPDI WGGNRTPEQE RYASSVLALN ATTGKLVWSY QTVHHDLWDM DLPSQPTLAD
     ITDKDGNTVP VIYAPAKTGN IFVLDRRTGK TVVPAPETPV PQGAAKGDHV SATQPYSELT
     FRPKQNLTDK DMWGATMYDQ LVCRVIFKRL RYEGPFTPPS EQGTLVFPGN LGMFEWGGIS
     VDPHRQIAIA NPMALPFVSK LIPRGPGNPE EPPKGATGGS GTETGIQPQY GVPYGVELNP
     FLSPFGLPCK QPAWGYVSAV DLKTNEVVWK QRIGTVRDSS PVPLPFKMGM PMLGGPVATA
     GKVFFIGATA DNYLRAFSTD TGELLWQARL PAGGQATPMT YEVNGKQYVV IAAGGHGSFG
     TKLGDYVIAY ALPDQK
//