UniProt: D4P8H2

Database: UniProt
Entry: D4P8H2_CAVPO

LinkDB:  D4P8H2_CAVPO 
Original site:  D4P8H2_CAVPO

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Ontology (5)   
   GO (5)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (18)   
   InterPro (11)   
   Pfam (5)   
   PROSITE (1)   
   SMART (1)   
All databases (24)   

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ID   D4P8H2_CAVPO            Unreviewed;       985 AA.
AC   D4P8H2;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084};
DE   Flags: Fragment;
GN   Name=ATP1a3 {ECO:0000313|EMBL:ADD82419.1};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|EMBL:ADD82419.1};
RN   [1] {ECO:0000313|EMBL:ADD82419.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Canning B.J., Marchese K.M.;
RT   "Cavia porcellus ATPase, Na+/K+ transporting, alpha 3 polypeptide.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362084};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IIC subfamily. {ECO:0000256|ARBA:ARBA00006934,
CC       ECO:0000256|RuleBase:RU362084}.
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DR   EMBL; GU585524; ADD82419.1; -; mRNA.
DR   AlphaFoldDB; D4P8H2; -.
DR   HOGENOM; CLU_002360_4_3_1; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:RHEA.
DR   CDD; cd02608; P-type_ATPase_Na-K_like; 1.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR005775; P-type_ATPase_IIC.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01106; ATPase-IIC_X-K; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 2.
DR   PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43294:SF15; SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00121; NAKATPASE.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362084};
KW   Hydrolase {ECO:0000313|EMBL:ADD82419.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU362084};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362084};
KW   Metal-binding {ECO:0000256|RuleBase:RU362084};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362084};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU362084};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU362084};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362084};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362084}; Transport {ECO:0000256|RuleBase:RU362084}.
FT   TRANSMEM        69..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        103..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        264..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        294..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        822..845
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        886..905
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        926..943
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        959..977
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   DOMAIN          15..89
FT                   /note="Cation-transporting P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00831"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADD82419.1"
FT   NON_TER         985
FT                   /evidence="ECO:0000313|EMBL:ADD82419.1"
SQ   SEQUENCE   985 AA;  108567 MW;  9FFCE2300E080ED4 CRC64;
     ERRDLDDLKK EVAMTEHKMS VEEVCRKYNT DCVQGLTHSK AQEILARDGP NALTPPPTTP
     EWVKFCRQLF GGFSILLWIG AILCFLAYGI QAGTEDDPSG DNLYLGIVLA AVVIITGCFS
     YYQEAKSSKI MESFKNMVPQ QALVIREGEK MQVNAEEVVV GDLVEIKGGD RVPADLRIIS
     AHGCKVDNSS LTGESEPQTR SPDCTHDNPL ETRNITFFST NCVEGTARGV VVATGDRTVM
     GRIATLASGL EVGKTPIAIE IEHFIQLITG VAVFLGVSFF ILSLILGYTW LEAVIFLIGI
     IVANVPEGLL ATVTVCLTLT AKRMARKNCL VKNLEAVETL GSTSTICSDK TGTLTQNRMT
     VAHMWFDNQI HEADTTEDQS GTSFDKSSHT WVALSHIAGL CNRAVFKGGQ DNIPVLKRDV
     AGDASESALL KCIELSSGSV KLMRERNKKV AEIPFNSTNK YQLSIHETED PNDNRYLLVM
     KGAPERILDR CSTILLQGKE QPLDEEMKEA FQNAYLELGG LGERVLGFCH YYLPEEQFPK
     GFAFDCDDVN FTTDNLCFVG LMSMIDPPRA AVPDAVGKCR SAGIKVIMVT GDHPITAKAI
     AKGVGIISEG NETVEDIAAR LNIPVSQVNP RDAKACVIHG TDLKDFTSEQ IDEILQNHTE
     IVFARTSPQQ KLIIVEGCQR QGAIVAVTGD GVNDSPALKK ADIGVAMGIA GSDVSKQAAD
     MILLDDNFAS IVTGVEEGRL IFDNLKKSIA YTLTSNIPEI TPFLLFIMAN IPLPLGTITI
     LCIDLGTDMV PAISLAYEAA ESDIMKRQPR NPRTDKLVNE RLISMAYGQI GMIQALGGFF
     SYFVILAENG FLPSNLVGIR LNWDDRTVND LEDSYGQQWT YEQRKVVEFT CHTAFFVSIV
     VVQWADLIIC KTRRNSVFQQ GMKNKILIFG LFEETALAAF LSYCPGMDVA LRMYPLKPSW
     WFCAFPYSFL IFVYDEIRKL ILRRN
//

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