ID D4PEB5_PRORE Unreviewed; 157 AA.
AC D4PEB5;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=dfrA1 {ECO:0000313|EMBL:ADD81213.1};
GN Synonyms=dhfrI {ECO:0000313|EMBL:CAB5708709.1};
GN ORFNames=GHA_03353 {ECO:0000313|EMBL:CAB5708709.1}, H0913_00185
GN {ECO:0000313|EMBL:QLR04874.1};
OS Providencia rettgeri.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Providencia.
OX NCBI_TaxID=587 {ECO:0000313|EMBL:ADD81213.1};
RN [1] {ECO:0000313|EMBL:ADD81213.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=58k {ECO:0000313|EMBL:ADD81213.1};
RA Aibinu I.E., Ogunsola F.T., Odugbemi T.O., Pfeifer Y., Koenig W.,
RA Ghebremedhin B.;
RT "First report of combined occurrence of blaCMY-4, blaOXA-10, blaVEB-1,
RT blaTEM-1 and qnrA1 in a Providencia rettgeri strain from Nigeria.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAB5708709.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BB1453 {ECO:0000313|EMBL:CAB5708709.1};
RA Delgado-Blas J.;
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QLR04874.1, ECO:0000313|Proteomes:UP000512070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZG2016M39-3 {ECO:0000313|EMBL:QLR04874.1,
RC ECO:0000313|Proteomes:UP000512070};
RA Zhou D.;
RT "Complete sequence of chromosome of strain ZG2016M39-3.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key enzyme in folate metabolism. Catalyzes an essential
CC reaction for de novo glycine and purine synthesis, and for DNA
CC precursor synthesis. {ECO:0000256|ARBA:ARBA00025067}.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|RuleBase:RU004474}.
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DR EMBL; GU945273; ADD81213.1; -; Genomic_DNA.
DR EMBL; CAHPSF010000010; CAB5708709.1; -; Genomic_DNA.
DR EMBL; CP059348; QLR04874.1; -; Genomic_DNA.
DR RefSeq; WP_000777554.1; NZ_VFQK01000083.1.
DR SMR; D4PEB5; -.
DR GeneID; 84572002; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000512070; Chromosome.
DR Proteomes; UP000834611; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAB5708709.1}.
FT DOMAIN 2..156
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 157 AA; 17575 MW; 487F818A40E4991B CRC64;
MKLSLMVAIS KNGVIGNGPD IPWSAKGEQL LFKAITYNQW LLVGRKTFES MGALPNRKYA
VVTRSSFTSD NENVLIFPSI KDALTNLKKI TDHVIVSGGG EIYKSLIDQV DTLHISTIDI
EPEGDVYFPE IPSNFRPVFT QDFASNINYS YQIWQKG
//
