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Database: UniProt
Entry: D4W3R1_9FIRM
LinkDB: D4W3R1_9FIRM
Original site: D4W3R1_9FIRM 
ID   D4W3R1_9FIRM            Unreviewed;       448 AA.
AC   D4W3R1;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   28-MAR-2018, entry version 52.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EFF64446.1};
GN   ORFNames=CUW_1813 {ECO:0000313|EMBL:EFF64446.1};
OS   Turicibacter sanguinis PC909.
OC   Bacteria; Firmicutes; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae; Turicibacter.
OX   NCBI_TaxID=702450 {ECO:0000313|EMBL:EFF64446.1, ECO:0000313|Proteomes:UP000002938};
RN   [1] {ECO:0000313|EMBL:EFF64446.1, ECO:0000313|Proteomes:UP000002938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC909 {ECO:0000313|EMBL:EFF64446.1,
RC   ECO:0000313|Proteomes:UP000002938};
RX   PubMed=21183674; DOI=10.1128/JB.01328-10;
RA   Cuiv P.O., Klaassens E.S., Durkin A.S., Harkins D.M., Foster L.,
RA   McCorrison J., Torralba M., Nelson K.E., Morrison M.;
RT   "Draft genome sequence of Turicibacter sanguinis PC909, isolated from
RT   human feces.";
RL   J. Bacteriol. 193:1288-1289(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFF64446.1}.
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DR   EMBL; ADMN01000042; EFF64446.1; -; Genomic_DNA.
DR   RefSeq; WP_006784011.1; NZ_ADMN01000042.1.
DR   ProteinModelPortal; D4W3R1; -.
DR   STRING; 702450.CUW_1813; -.
DR   EnsemblBacteria; EFF64446; EFF64446; CUW_1813.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002938; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002938};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002938}.
FT   DOMAIN      141    270       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      357    426       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     149    156       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      423    446       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   448 AA;  51928 MW;  E3290C85C52C8BB7 CRC64;
     MEKYQRIWDD AINRLKSNIS QQSFDMFFST PKKVYKVKNN KMYVIVQNNH EQFMLDKFYL
     KELVEMIAEV SGFNYDVKFI TNDYVKNDQQ AFDLTKPDPN LPKYYRGNLN TTYTFDRFVA
     GKSNRLAYMI ALQVAERPGE VANPLYIFGG VGLGKTHLMQ AIGNFILDDN PSSRILYCTS
     EKFIDDYRHA TLDNNFEAFK EKYRNIDVLL IDDIQFLSKK EQTQTEFFNT FNELYNNNKQ
     IVITSDRPAS DLKDIMDRLT SRFEWGLQAD IQIPDTQTRI EIMKKKLAGE NINLDEFPEE
     VLEFIASKFN SNVRTLEGAL KRLIFYATIN NSDFTIELAN EALRDLFKAE QKNSKIDVNN
     IIKEVGAYYD VSVADILSKK RKKNIAYARQ VAMFLTRELT GSSFPKIGEA FSGRDHTTIM
     HGCEKIEKEL KESAELKKAI NDLKQALS
//
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