ID D4YUY7_9LACO Unreviewed; 252 AA.
AC D4YUY7;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN Name=rnhA {ECO:0000313|EMBL:EFG55038.1};
GN ORFNames=HMPREF0493_1348 {ECO:0000313|EMBL:EFG55038.1};
OS Lactobacillus amylolyticus DSM 11664.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=585524 {ECO:0000313|EMBL:EFG55038.1, ECO:0000313|Proteomes:UP000004069};
RN [1] {ECO:0000313|EMBL:EFG55038.1, ECO:0000313|Proteomes:UP000004069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11664 {ECO:0000313|EMBL:EFG55038.1,
RC ECO:0000313|Proteomes:UP000004069};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the RNase H family.
CC {ECO:0000256|ARBA:ARBA00005300}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFG55038.1}.
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DR EMBL; ADNY01000055; EFG55038.1; -; Genomic_DNA.
DR RefSeq; WP_006352497.1; NZ_AZEP01000009.1.
DR AlphaFoldDB; D4YUY7; -.
DR STRING; 83683.B1745_00640; -.
DR PATRIC; fig|585524.9.peg.1639; -.
DR eggNOG; COG0328; Bacteria.
DR eggNOG; COG3341; Bacteria.
DR OrthoDB; 9811552at2; -.
DR Proteomes; UP000004069; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd09278; RNase_HI_prokaryote_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR InterPro; IPR009027; Ribosomal_bL9/RNase_H1_N.
DR InterPro; IPR017067; RNase_H1_euk.
DR InterPro; IPR011320; RNase_H1_N.
DR InterPro; IPR037056; RNase_H1_N_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR022892; RNaseHI.
DR PANTHER; PTHR10642; RIBONUCLEASE H1; 1.
DR PANTHER; PTHR10642:SF26; RIBONUCLEASE H1; 1.
DR Pfam; PF01693; Cauli_VI; 1.
DR Pfam; PF00075; RNase_H; 1.
DR PIRSF; PIRSF036852; Ribonuclease_H1_euk; 2.
DR SUPFAM; SSF55658; L9 N-domain-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EFG55038.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004069}.
FT DOMAIN 93..249
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
SQ SEQUENCE 252 AA; 28909 MW; AE590BDE3C88D5FF CRC64;
MKFYAVKKGR KPGIYRNWDE AKAQVDGFSG AEYKSFAQIT DATDYLNWNK ETQGQEIRKD
EDNLQNAIKK IVNTSKKLPV QTKTVKARNS NPNDYFATIY TDGGTRNTGV YKGGHVKKTD
KAAWAYRIEW GDQEVHGAGG EYGATNNKME QTGFINALKK LIELGFNDKK LLFVLDSQYV
LNAINKGWLK SWKKRGWKKS SGPLANKEEW QEIDRLLTKF PNAKFEWTKG HANNAGNEFV
DHFLNKYMDE KM
//
