ID D5A9B8_PICSI Unreviewed; 483 AA.
AC D5A9B8;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Uridine 5'-monophosphate synthase {ECO:0000256|ARBA:ARBA00015047};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
OS Picea sitchensis (Sitka spruce) (Pinus sitchensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Pinopsida; Pinidae; Conifers I; Pinales; Pinaceae; Picea.
OX NCBI_TaxID=3332 {ECO:0000313|EMBL:ADE76137.1};
RN [1] {ECO:0000313|EMBL:ADE76137.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bud {ECO:0000313|EMBL:ADE76137.1};
RA Reid K.E., Liao N., Chan S., Docking R., Taylor G., Moore R., Mayo M.,
RA Munro S., King J., Yanchuk A., Holt R., Jones S., Marra M., Ritland C.E.,
RA Ritland K., Bohlmann J.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the OMP decarboxylase
CC family. {ECO:0000256|ARBA:ARBA00009769}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the purine/pyrimidine
CC phosphoribosyltransferase family. {ECO:0000256|ARBA:ARBA00006221}.
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DR EMBL; BT122784; ADE76137.1; -; mRNA.
DR AlphaFoldDB; D5A9B8; -.
DR UniPathway; UPA00070; UER00119.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04725; OMP_decarboxylase_like; 1.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014732; OMPdecase.
DR InterPro; IPR018089; OMPdecase_AS.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR00336; pyrE; 1.
DR NCBIfam; TIGR01740; pyrF; 1.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR PROSITE; PS00156; OMPDECASE; 1.
PE 2: Evidence at transcript level;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}.
FT DOMAIN 247..465
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 483 AA; 51872 MW; BA0EB0017F74A7F6 CRC64;
MEELILELHK VEAVKFGNFT LKSGIISPIY IDLRLIVSYP HLLKLVSETI WNKVSSLKFE
LICGVPYTAL PIATCISLAH SVPMVMRRKE VKDYGTKKSI EGVFSPGQTC LVIEDLVTSG
ASVLETVGPL KSVGLNVSDT VVLIDREQGG SDNLANNGIA LHSALKLTQM VDVLVRHSKL
SAEIADSVRK FIAENQTKVP VPSPSPSLAP APVDGVRKRS SYGERAALAQ NPTGRKLFEL
MERKKTNLSL AADVSTAQQL VCIADAVGPE ICVLKTHVDI LPDFTPDFGA QLRAIADKHD
FLIFEDRKFA DIGNTVTMQY EGGIFKIVEW ADVVNAHVIP GPGIVEGLKL KGLPHGRGLL
LLAEMSSAGT LAKGEYTSAA VKIASDHPDF VIGFISINPA AWPEGPGNPA LIHMTPGVQL
SSGGDTLGQQ YNTPDSVIGE RGSDVIIVGR GIIKAKDQVM AARQYRIAGW NAYEKNVKMG
GGL
//
