ID D5AWG5_RICPP Unreviewed; 355 AA.
AC D5AWG5;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Multidrug resistance protein A {ECO:0000313|EMBL:ADE29754.1};
GN Name=emrA {ECO:0000313|EMBL:ADE29754.1};
GN OrderedLocusNames=rpr22_CDS237 {ECO:0000313|EMBL:ADE29754.1};
OS Rickettsia prowazekii (strain Rp22).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=449216 {ECO:0000313|EMBL:ADE29754.1, ECO:0000313|Proteomes:UP000006931};
RN [1] {ECO:0000313|EMBL:ADE29754.1, ECO:0000313|Proteomes:UP000006931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rp22 {ECO:0000313|EMBL:ADE29754.1,
RC ECO:0000313|Proteomes:UP000006931};
RX PubMed=20368341; DOI=10.1101/gr.103564.109;
RA Bechah Y., El Karkouri K., Mediannikov O., Leroy Q., Pelletier N.,
RA Robert C., Medigue C., Mege J.L., Raoult D.;
RT "Genomic, proteomic, and transcriptomic analysis of virulent and avirulent
RT Rickettsia prowazekii reveals its adaptive mutation capabilities.";
RL Genome Res. 20:655-663(2010).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP001584; ADE29754.1; -; Genomic_DNA.
DR AlphaFoldDB; D5AWG5; -.
DR KEGG; rpq:rpr22_CDS237; -.
DR PATRIC; fig|449216.3.peg.247; -.
DR HOGENOM; CLU_018816_15_1_5; -.
DR Proteomes; UP000006931; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF26; TRANSPORT PROTEIN COMB; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..351
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 160..303
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 165..220
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 355 AA; 39965 MW; 53FBFEDA114B5D01 CRC64;
MVKCVMFSVL QQVIYKYKHY SFIKHVIIIV LIIFTYFGYR IYVWANTQST DNAYIDADIS
NISAEVSGVL TKLFVTNNTR VNKGELIGEI DDRDYKARLA ALDAAIQACI KNIEIIEQKI
SIGKMRLEQV AEKLKLTKIS FDIISIDFTR VQALSNAKFV SSKTLDDSKN EYQKVKTEYK
QAQLDLDISK HNLQLLELEK SAAQEKLKEL TENKKITLRS LQNTKIIAMV PGIFSNSNLA
VGNYIVMGKA LFSIVQDNTM YIKANFKETQ IKNFKSGMKV KIVFDAFPTK VIYGKIRNIA
PATGAKFSLI PPDNATGNFT KIVQRVSVLI DFVSPNANLV PGMSARVSIR TDQST
//
