ID D5CMW0_SIDLE Unreviewed; 694 AA.
AC D5CMW0;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093};
GN OrderedLocusNames=Slit_0556 {ECO:0000313|EMBL:ADE10796.1};
OS Sideroxydans lithotrophicus (strain ES-1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Gallionellaceae; Sideroxydans.
OX NCBI_TaxID=580332 {ECO:0000313|EMBL:ADE10796.1, ECO:0000313|Proteomes:UP000001625};
RN [1] {ECO:0000313|EMBL:ADE10796.1, ECO:0000313|Proteomes:UP000001625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ES-1 {ECO:0000313|EMBL:ADE10796.1,
RC ECO:0000313|Proteomes:UP000001625};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Emerson D., Woyke T.;
RT "Complete sequence of Sideroxydans lithotrophicus ES-1.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
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DR EMBL; CP001965; ADE10796.1; -; Genomic_DNA.
DR RefSeq; WP_013028695.1; NC_013959.1.
DR AlphaFoldDB; D5CMW0; -.
DR STRING; 580332.Slit_0556; -.
DR KEGG; slt:Slit_0556; -.
DR eggNOG; COG1298; Bacteria.
DR HOGENOM; CLU_015346_3_0_4; -.
DR OrthoDB; 9759185at2; -.
DR Proteomes; UP000001625; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:ADE10796.1};
KW Cilium {ECO:0000313|EMBL:ADE10796.1};
KW Flagellum {ECO:0000313|EMBL:ADE10796.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000001625};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 66..85
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 120..138
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 206..228
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 248..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 308..325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 694 AA; 74300 MW; 5D98A9FA0341C280 CRC64;
MNMLEMLRGA MLRGGVRGLA GPILIVMILS MMVLPLPPFL LDILFTFNIA LSIMVLLVAM
NTTKPLDFAV FPTVLLISTL LRLSLNVAST RVVLLRGHTG PDAAGKVIES FGHFLVGGNY
TVGIVVFVIL VVINFVVITK GAGRIAEVGA RFTLDAMPGK QMAIDADLNA GLIGEDMARK
RRAEIAQEAD FYGAMDGASK FVRGDAVAGI IIMLINIVGG LVVGVLQHNL DLATAATNYT
LLTIGDGLVA QIPALVISTA AGMVVSRVAS DDSIGQQLAK QLVSSPQVLI LTAAIVGTLG
MIPGMPHFAF LLLAGLLGWF AFFLLQRTQQ EAVKAAAAEN PVVAQSTEAP EASWEDVAQV
DVLGLEVGYR LISLVDKAQD GDLLRRIKGI RKKFTQDMGF LPPAVHIRDN LELRPNGYRI
TLKGAEIGSG EAYPNMFLAI NPGSVSGTLP GTPTKDPAFG LPAVWVDAAV REQAQVMGYT
VVDAGTVVAT HMSHLIHTHA AELLGRQELQ QLLDHLGKLA PKLTEDLIPK LLPLATVQKV
LQNLLDEGMH IRDMRTILET LAEHAVHTQD AIVLTGLVRI ALGAAIVQQF YPSAQELQVI
GMDKELEYVL AQALQAGGSA IEPSLANTLL REARTATQTQ EQMGLPAVLL VPGHIRDLLA
RFLKRSLPQL RVISQEEVPG FKTVRFTSMV GGRA
//
