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Database: UniProt
Entry: D5EKE9_CORAD
LinkDB: D5EKE9_CORAD
Original site: D5EKE9_CORAD 
ID   D5EKE9_CORAD            Unreviewed;       469 AA.
AC   D5EKE9;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   25-OCT-2017, entry version 55.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Caka_0001 {ECO:0000313|EMBL:ADE53030.1};
OS   Coraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193
OS   / KCTC 12865 / 04OKA010-24).
OC   Bacteria; Verrucomicrobia; Opitutae; Puniceicoccales;
OC   Puniceicoccaceae; Coraliomargarita.
OX   NCBI_TaxID=583355 {ECO:0000313|EMBL:ADE53030.1, ECO:0000313|Proteomes:UP000000925};
RN   [1] {ECO:0000313|EMBL:ADE53030.1, ECO:0000313|Proteomes:UP000000925}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865
RC   {ECO:0000313|Proteomes:UP000000925};
RX   PubMed=21304713; DOI=10.4056/sigs.952166;
RA   Mavromatis K., Abt B., Brambilla E., Lapidus A., Copeland A.,
RA   Deshpande S., Nolan M., Lucas S., Tice H., Cheng J.F., Han C.,
RA   Detter J.C., Woyke T., Goodwin L., Pitluck S., Held B., Brettin T.,
RA   Tapia R., Ivanova N., Mikhailova N., Pati A., Liolios K., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT   "Complete genome sequence of Coraliomargarita akajimensis type strain
RT   (04OKA010-24).";
RL   Stand. Genomic Sci. 2:290-299(2010).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001998; ADE53030.1; -; Genomic_DNA.
DR   RefSeq; WP_013041756.1; NC_014008.1.
DR   ProteinModelPortal; D5EKE9; -.
DR   STRING; 583355.Caka_0001; -.
DR   EnsemblBacteria; ADE53030; ADE53030; Caka_0001.
DR   KEGG; caa:Caka_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000925; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000925};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000925}.
FT   DOMAIN      162    282       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      374    443       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     170    177       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   469 AA;  53136 MW;  45B0D7D29C98979D CRC64;
     MPNSTPTLSL WESVNNELKS LFPADLYDMW FDDLKCVEQS EQKIVLAAPN EFNAIWIENN
     YLDVIAQQAR SFAGAQVEIS VLVDEVADEA VTVERTNRLS AKSKQSDRVV PTVAARTEGA
     KAPQARRTLL NPRNTFENFV VGSGNQLAHA ASIAVANAPG RAYNPLFVFG ETGLGKTHLM
     HAVAHQMLVN NPNARIAYVS TEKFTNEFIR AIQENKLAKF RKYYRTVDAL LVDDIHFLSG
     KESTQEEFFH TFNDLFESGR QIFLASDRPA NEIERLENRL ISRFQWGLVT DMQAPDYETR
     VAILRKKAIA MDITLDDSIV DFLAERVSRN VRRMEGALTR IASYNSLMNR QLDLDGVERL
     LSDLFQEEAA SKVTVEQIQK KVSEYYQIRY SDLIGRRRTS SIVFPRQVAM YISRTLTSDP
     LKSIGDAFGG RDHGTVIHAC KQVENMMEQD GTVKRAVDYL IKQLSHNRV
//
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