ID D5K564_HELPX Unreviewed; 152 AA.
AC D5K564;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 13-SEP-2023, entry version 42.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE Flags: Fragment;
GN Name=trpC {ECO:0000313|EMBL:ADE42119.1};
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210 {ECO:0000313|EMBL:ADE42119.1};
RN [1] {ECO:0000313|EMBL:ADE42119.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SLN077 {ECO:0000313|EMBL:ADE42119.1};
RX PubMed=20339588; DOI=10.1371/journal.pone.0009645;
RA Latifi-Navid S., Ghorashi S.A., Siavoshi F., Linz B., Massarrat S.,
RA Khegay T., Salmanian A.H., Shayesteh A.A., Masoodi M., Ghanadi K.,
RA Ganji A., Suerbaum S., Achtman M., Malekzadeh R., Falush D.;
RT "Ethnic and geographic differentiation of Helicobacter pylori within
RT Iran.";
RL PLoS ONE 5:E9645-E9645(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR EMBL; GU444951; ADE42119.1; -; Genomic_DNA.
DR AlphaFoldDB; D5K564; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Isomerase {ECO:0000313|EMBL:ADE42119.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 1..152
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADE42119.1"
FT NON_TER 152
FT /evidence="ECO:0000313|EMBL:ADE42119.1"
SQ SEQUENCE 152 AA; 16992 MW; 0179621FE7E5B863 CRC64;
CISVLADSKY FLGSYENIKI VSQHSTKPIL CKDFIIDAFQ IKLARVMGAD AVLLMLSALD
DKNYLELFNL AKSLNMSVLT EVSNQQEIKR LLKLQYDIIG INNRDLHTLT TDINNTLKLR
SLLPKDVLVV SESGIHSHAQ IKALAPHVNG FL
//
