ID D5K566_HELPX Unreviewed; 152 AA.
AC D5K566;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 13-SEP-2023, entry version 42.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE Flags: Fragment;
GN Name=trpC {ECO:0000313|EMBL:ADE42121.1};
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210 {ECO:0000313|EMBL:ADE42121.1};
RN [1] {ECO:0000313|EMBL:ADE42121.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SLN079 {ECO:0000313|EMBL:ADE42121.1};
RX PubMed=20339588; DOI=10.1371/journal.pone.0009645;
RA Latifi-Navid S., Ghorashi S.A., Siavoshi F., Linz B., Massarrat S.,
RA Khegay T., Salmanian A.H., Shayesteh A.A., Masoodi M., Ghanadi K.,
RA Ganji A., Suerbaum S., Achtman M., Malekzadeh R., Falush D.;
RT "Ethnic and geographic differentiation of Helicobacter pylori within
RT Iran.";
RL PLoS ONE 5:E9645-E9645(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR EMBL; GU444953; ADE42121.1; -; Genomic_DNA.
DR AlphaFoldDB; D5K566; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Isomerase {ECO:0000313|EMBL:ADE42121.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 1..152
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADE42121.1"
FT NON_TER 152
FT /evidence="ECO:0000313|EMBL:ADE42121.1"
SQ SEQUENCE 152 AA; 16988 MW; 2778B6C29C73F405 CRC64;
CVSVLADSKY FLGSYENIKI VSQHSTKPVL CKDFIIDAFQ IKLARVMGAN AVLLMLSALD
DKNYLELFNL AKSLNMSVLT EVSNKQEIER LLKLQYDIIG INNRDLHTLT TDINNTLKLR
SLLPKDALVV SESGIYSHAQ IKALAPYVNG FL
//
