ID   D5L2Z4_LISMN            Unreviewed;       800 AA.
AC   D5L2Z4;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=InlA {ECO:0000313|EMBL:ADE73850.1};
GN   Name=inlA {ECO:0000313|EMBL:ADE73850.1};
OS   Listeria monocytogenes.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=1639 {ECO:0000313|EMBL:ADE73850.1};
RN   [1] {ECO:0000313|EMBL:ADE73850.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3272-03 {ECO:0000313|EMBL:ADE73850.1};
RX   PubMed=20348313; DOI=10.1128/AEM.02862-09;
RA   Holch A., Gottlieb C.T., Larsen M.H., Ingmer H., Gram L.;
RT   "Poor invasion of trophoblastic cells but normal plaque formation in
RT   fibroblastic cells despite actA deletion in a group of Listeria
RT   monocytogenes strains persisting in some food processing environments.";
RL   Appl. Environ. Microbiol. 76:3391-3397(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the internalin family.
CC       {ECO:0000256|ARBA:ARBA00009432}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GU735671; ADE73850.1; -; Genomic_DNA.
DR   AlphaFoldDB; D5L2Z4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.1220; -; 1.
DR   Gene3D; 2.60.40.4270; Listeria-Bacteroides repeat domain; 3.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR012569; Inl_IR.
DR   InterPro; IPR047600; InlA.
DR   InterPro; IPR013378; InlB-like_B-rpt.
DR   InterPro; IPR024634; Internalin_N.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   NCBIfam; NF033189; internalin_A; 1.
DR   NCBIfam; TIGR02543; List_Bact_rpt; 3.
DR   NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR   PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR   Pfam; PF09479; Flg_new; 3.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF12354; Internalin_N; 1.
DR   Pfam; PF12799; LRR_4; 6.
DR   Pfam; PF08191; LRR_adjacent; 1.
DR   SMART; SM00365; LRR_SD22; 13.
DR   SMART; SM00369; LRR_TYP; 12.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR   PROSITE; PS51450; LRR; 13.
PE   3: Inferred from homology;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          767..800
FT                   /note="Gram-positive cocci surface proteins LPxTG"
FT                   /evidence="ECO:0000259|PROSITE:PS50847"
FT   REGION          705..757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   800 AA;  86516 MW;  3FD0638CD565B508 CRC64;
     MRRKRYVWLK SILVAILVFG SGVWINTSNG TNAQAATITQ DTPINQIFTD AALAEKMKTV
     LGKTNVTDTV SQTDLDQVTT LQADRLGIKS IDGVEYLNNL TQINFSNNQL TDITPLKNLT
     KLVDILMNNN QIADITPLAN LTNLTGLTLF NNQITDLDPL KNLTNLNRLE LSSNTISDIS
     ALSGLTSLQQ LSFGNQVTDL KPLANLTTLE RLDISSNKVS DISVLAKLTN LESLIATNNQ
     ISDITPLGIL TNLDELSLNG NQLKDIGTLA SLTNLTDLDL ANNQISNLAP LSGLTKLTEL
     KLGANQISNI SPLAGLTALT NLELNENQLE DISPISNLKN LTYLTLYFNN ISDISPVSSL
     TKLQRLFFYN NKVSDVSSLA NLTNINWLSA GHNQISDLTP LANLTRITQL GLNDQAWTNA
     PVNYKANVSI PNTVKNVTGA LIAPATISDG GSYTEPDITW NLPSYTNEVS YTFNQSVTIG
     KGTTTFSGTV TQPLKAIFNA KFHVDGKETT KKVDAGNLLT EPAKPVKEGY TFIGWFDAQT
     GGTKWNFSTD KMPTNDIDLY AQFSINSYTA TLDNDGVTTS QTVDYQGLLQ EPTAPTKEGY
     TFKGWYDAKT GGDKWDFATS KMPAKNITLY AQYSANSYTA TFDVDGKTTT QAVDYQGLLK
     EPKTPTKAGY TFKGWYDEKT DGKKWDFATD KMPANDITLY AQFTKNPVAP PTTGGNTPPT
     TNNGGNTTPP SANIPGSDTS NTSTGNSAST TSTMNAYDPY NSKEASLPTT GDSDNALYLL
     LGLLAVGTAM ALTKKARASK
//