ID D5LKC7_BIFLI Unreviewed; 203 AA.
AC D5LKC7;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Urease accessory protein UreG {ECO:0000256|HAMAP-Rule:MF_01389};
GN Name=ureG {ECO:0000256|HAMAP-Rule:MF_01389,
GN ECO:0000313|EMBL:ADE67059.1};
GN ORFNames=B5785_0170 {ECO:0000313|EMBL:OQM70774.1}, BFS25_10620
GN {ECO:0000313|EMBL:OIN61422.1}, BLJG463_01471
GN {ECO:0000313|EMBL:VUX34255.1}, E6L38_00745
GN {ECO:0000313|EMBL:THJ30608.1}, HNS28_01490
GN {ECO:0000313|EMBL:NQX50192.1}, RY67_771 {ECO:0000313|EMBL:ALE08825.1};
OS Bifidobacterium longum subsp. infantis.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1682 {ECO:0000313|EMBL:ADE67059.1};
RN [1] {ECO:0000313|EMBL:ADE67059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=R0033 {ECO:0000313|EMBL:ADE67059.1};
RA de Carvalho V., Tompkins T.A.;
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADE67059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=R0033 {ECO:0000313|EMBL:ADE67059.1};
RA Cazzola M., Matera M.G., Tompkins T.A.;
RT "Immunomodulatory Impact of a Symbiotic in TH1 and TH2 Models of
RT Infection.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ALE08825.1, ECO:0000313|Proteomes:UP000067206}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BT1 {ECO:0000313|EMBL:ALE08825.1,
RC ECO:0000313|Proteomes:UP000067206};
RA Kim J.F., Kwak M.-J.;
RT "Complete genome sequence of Bifidobacterium longum subsp. infantis BT1.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OIN61422.1, ECO:0000313|Proteomes:UP000181741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TPY12-1 {ECO:0000313|EMBL:OIN61422.1,
RC ECO:0000313|Proteomes:UP000181741};
RX PubMed=27782805;
RA Bunesova V., Lacroix C., Schwab C.;
RT "Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum
RT and Bifidobacterium kashiwanohense.";
RL BMC Microbiol. 16:248-248(2016).
RN [5] {ECO:0000313|EMBL:OQM70774.1, ECO:0000313|Proteomes:UP000192279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1888B {ECO:0000313|EMBL:OQM70774.1,
RC ECO:0000313|Proteomes:UP000192279};
RA Lugli G.A., Duranti S., Milani C., Mancabelli L.;
RT "Maternal inheritance of bifidobacteria.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:THJ30608.1, ECO:0000313|Proteomes:UP000306697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UBBI-01 {ECO:0000313|EMBL:THJ30608.1,
RC ECO:0000313|Proteomes:UP000306697};
RA Sulthana A., Lakshmi S.G., Madempudi R.S.;
RT "Genome Announcement To Ensure Probiotic Safety of Bifidobacterium longum
RT subsp infantis UBBI-01.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:VUX34255.1, ECO:0000313|Proteomes:UP000345266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bifidobacterium_longum_subsp_infantis_JG_Bg463
RC {ECO:0000313|EMBL:VUX34255.1};
RA Hibberd C M., Gehrig L. J., Chang H.-W., Venkatesh S.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:NQX50192.1, ECO:0000313|Proteomes:UP000551316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BI-G201 {ECO:0000313|EMBL:NQX50192.1,
RC ECO:0000313|Proteomes:UP000551316};
RA Song J., Xu Y., Han D., Teng Q., Jiang D., Liu Q.;
RT "Draft Genome Sequence of Bifidobacterium longum subsp. Infantis BI-G201, a
RT Commercialization Strain.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Facilitates the functional incorporation of the urease nickel
CC metallocenter. This process requires GTP hydrolysis, probably
CC effectuated by UreG. {ECO:0000256|HAMAP-Rule:MF_01389}.
CC -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts as a
CC GTP-hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000256|HAMAP-Rule:MF_01389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01389}.
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC subfamily. {ECO:0000256|ARBA:ARBA00005732, ECO:0000256|HAMAP-
CC Rule:MF_01389}.
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DR EMBL; GU936671; ADE67059.1; -; Genomic_DNA.
DR EMBL; CP010411; ALE08825.1; -; Genomic_DNA.
DR EMBL; JABNND010000003; NQX50192.1; -; Genomic_DNA.
DR EMBL; MOAF01000044; OIN61422.1; -; Genomic_DNA.
DR EMBL; NAQJ01000002; OQM70774.1; -; Genomic_DNA.
DR EMBL; SSWL01000001; THJ30608.1; -; Genomic_DNA.
DR EMBL; CABHNT010000033; VUX34255.1; -; Genomic_DNA.
DR RefSeq; WP_032745053.1; NZ_WBNV01000002.1.
DR PATRIC; fig|1682.24.peg.745; -.
DR Proteomes; UP000067206; Chromosome.
DR Proteomes; UP000181741; Unassembled WGS sequence.
DR Proteomes; UP000192279; Unassembled WGS sequence.
DR Proteomes; UP000306697; Unassembled WGS sequence.
DR Proteomes; UP000345266; Unassembled WGS sequence.
DR Proteomes; UP000551316; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR CDD; cd05540; UreG; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01389; UreG; 1.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004400; UreG.
DR NCBIfam; TIGR00101; ureG; 1.
DR PANTHER; PTHR31715; UREASE ACCESSORY PROTEIN G; 1.
DR PANTHER; PTHR31715:SF0; UREASE ACCESSORY PROTEIN G; 1.
DR Pfam; PF02492; cobW; 1.
DR PIRSF; PIRSF005624; Ni-bind_GTPase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01389};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01389};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW Rule:MF_01389};
KW Nickel insertion {ECO:0000256|ARBA:ARBA00022988, ECO:0000256|HAMAP-
KW Rule:MF_01389};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01389}.
FT DOMAIN 6..175
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01389"
SQ SEQUENCE 203 AA; 22261 MW; DA7257774526EA8C CRC64;
MSYVRIGVAG PVGSGKTALI ERLTRKMADD YSICVVTNDI YTKEDAEFLI ANSRLPEDRI
VGVETGGCPH TAIREDCSMN LEACEAMAMS HPDVDIIFVE SGGDNLSATF SPDLADATIY
VIATDEGDKI PRKGGPGVTR SDLLVINKTD IADLVHADLN VMARDSERMR NGRPYLFTDL
MNDKGVDDVI AWIRKSVLFE DMR
//
