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Database: UniProt
Entry: D5RHZ7_9PROT
LinkDB: D5RHZ7_9PROT
Original site: D5RHZ7_9PROT 
ID   D5RHZ7_9PROT            Unreviewed;       402 AA.
AC   D5RHZ7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Beta-ketoadipyl CoA thiolase {ECO:0000313|EMBL:EFH13079.1};
DE            EC=2.3.1.- {ECO:0000313|EMBL:EFH13079.1};
GN   Name=pcaF {ECO:0000313|EMBL:EFH13079.1};
GN   ORFNames=HMPREF0731_0707 {ECO:0000313|EMBL:EFH13079.1};
OS   Pseudoroseomonas cervicalis ATCC 49957.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Pseudoroseomonas.
OX   NCBI_TaxID=525371 {ECO:0000313|EMBL:EFH13079.1, ECO:0000313|Proteomes:UP000005324};
RN   [1] {ECO:0000313|EMBL:EFH13079.1, ECO:0000313|Proteomes:UP000005324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49957 {ECO:0000313|EMBL:EFH13079.1,
RC   ECO:0000313|Proteomes:UP000005324};
RA   Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA   Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA   Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA   Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA   Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA   Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA   Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA   Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA   Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA   Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA;
CC         Xref=Rhea:RHEA:19481, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:57348; EC=2.3.1.174;
CC         Evidence={ECO:0000256|ARBA:ARBA00000708};
CC   -!- PATHWAY: Aromatic compound metabolism. {ECO:0000256|ARBA:ARBA00005211}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFH13079.1}.
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DR   EMBL; ADVL01000122; EFH13079.1; -; Genomic_DNA.
DR   RefSeq; WP_007003766.1; NZ_GG770778.1.
DR   AlphaFoldDB; D5RHZ7; -.
DR   HOGENOM; CLU_031026_2_2_5; -.
DR   OrthoDB; 9764638at2; -.
DR   Proteomes; UP000005324; Unassembled WGS sequence.
DR   GO; GO:0033812; F:3-oxoadipyl-CoA thiolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019619; P:3,4-dihydroxybenzoate catabolic process; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR012793; PcaF.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   NCBIfam; TIGR02430; pcaF; 1.
DR   PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR   PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA/3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:EFH13079.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005324};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003557}.
FT   DOMAIN          5..269
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          279..401
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        90
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        358
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        388
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   402 AA;  42153 MW;  F46F2894EF38A78E CRC64;
     MRDAYICDAA RTPIGRYAGA LAPVRADDLG AIPIKALMAR HPDLDWAALD DVVFGCANQA
     GEDNRNVARM SSLLAGLPDS VPGSTVNRLC GSGMDATGIA ARAIKSGEAE LMLAGGVESM
     TRAPFVQGKS AEAFGRAAEI HDTTIGWRFV NPLMKAQYGV DSMPETAENV AADFQISRAD
     QDLFAFRSQQ RAKAAQAAGR FAREIVPVEI KRRKGETLIV AQDEHPRPET TLEALAKLPT
     PFRREGGSVT AGNASGVNDG ACAILLASAD AAARHGLVPR ARVVASATAG VPPRIMGFGP
     APAVRRVLDK AGLSLSQMDV IELNEAFAAQ ALAVTRDLGL PDDAEHVNPN GGAIALGHPL
     GMSGARLVQT AVEELHLRQA RYALVTMCIG VGQGIAMILE RA
//
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