ID   D5SHR5_DROME            Unreviewed;       589 AA.
AC   D5SHR5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Kelch-like protein diablo {ECO:0000256|ARBA:ARBA00013699};
DE   Flags: Fragment;
GN   Name=CG17754-RA {ECO:0000313|EMBL:ADG03451.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ADG03451.1};
RN   [1] {ECO:0000313|EMBL:ADG03451.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT124866; ADG03451.1; -; mRNA.
DR   AlphaFoldDB; D5SHR5; -.
DR   EnsemblMetazoa; FBtr0071314; FBpp0071249; FBgn0030114.
DR   VEuPathDB; VectorBase:FBgn0030114; -.
DR   UniPathway; UPA00143; -.
DR   Bgee; FBgn0030114; Expressed in eye disc (Drosophila) and 24 other cell types or tissues.
DR   ExpressionAtlas; D5SHR5; baseline and differential.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd18234; BTB_POZ_KLHL1-like; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   Gene3D; 2.130.10.80; Galactose oxidase/kelch, beta-propeller; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR037293; Gal_Oxidase_central_sf.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF3; KELCH-LIKE PROTEIN DIABLO; 1.
DR   PANTHER; PTHR45632; LD33804P; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 5.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          23..79
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADG03451.1"
SQ   SEQUENCE   589 AA;  65460 MW;  4D428AC886ED06A7 CRC64;
     ALFDFAALNR FWIVKTCRSV PWVPAHRLVL SASSAYFSAM FTGSLRETKE QEVTLGEVHG
     DALHLLVQYC YTGFIEMRED TVETLLATAC LLQLNAVVTA CCNFLARQLH PSNCLGFAFF
     AEQQSCTTLL RLAQAYTCQY FMQVCQNQEF FQLNADQLGK LLSSDDLNVP SEQDVFHSLM
     SWVRHDSAAR EQHIPELLAL VRLPLLQPAF IMDHVENVCN ANECQQLVME AFKWHLMPER
     RSRIATERTT PRKSTVGRLL AVGGMDAHKG AISIESYCPR LDKWTPWKHM TGRRLQFGAA
     VMEDKLILVG GRDGLKTLNT VESLDLNTMA WAPLNAMATP RHGLGVAVLE GPLYAVGGHD
     GWSYLNTVER WDPIARTWSY VAPMSSMRST AGVAVLGGRL YAVGGRDGSV CHRSIECYDP
     HTNKWSLLAP MNRRRGGVGV TVANGFLYAL GGHDCPASNP MVCRTETVER YDPATDTWTL
     ICSLALGRDA IGCALLGDRL IVVGGYDGNH ALKSVEEYDP VRNGWNELAP MAFARAGACV
     VAIPNVIPPA AQQPPPSATK KKKWKPVRLD PICYNRRPRC VEFVDYYNM
//