ID D5SLK0_STRCL Unreviewed; 887 AA.
AC D5SLK0;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:EFG04793.2};
GN ORFNames=SCLAV_p1307 {ECO:0000313|EMBL:EFG04793.2};
OS Streptomyces clavuligerus.
OG Plasmid pSCL4 {ECO:0000313|EMBL:EFG04793.2,
OG ECO:0000313|Proteomes:UP000002357}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1901 {ECO:0000313|EMBL:EFG04793.2, ECO:0000313|Proteomes:UP000002357};
RN [1] {ECO:0000313|EMBL:EFG04793.2, ECO:0000313|Proteomes:UP000002357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 /
RC NRRL 3585 / VKM Ac-602 {ECO:0000313|Proteomes:UP000002357};
RC PLASMID=pSCL4 {ECO:0000313|EMBL:EFG04793.2};
RX PubMed=20624727; DOI=10.1093/gbe/evq013;
RA Medema M.H., Trefzer A., Kovalchuk A., van den Berg M., Mueller U.,
RA Heijne W., Wu L., Alam M.T., Ronning C.M., Nierman W.C., Bovenberg R.A.L.,
RA Breitling R., Takano E.;
RT "The sequence of a 1.8-mb bacterial linear plasmid reveals a rich
RT evolutionary reservoir of secondary metabolic pathways.";
RL Genome Biol. Evol. 2:212-224(2010).
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DR EMBL; CM000914; EFG04793.2; -; Genomic_DNA.
DR RefSeq; WP_003963616.1; NZ_WKJU01000565.1.
DR AlphaFoldDB; D5SLK0; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000002357; Plasmid pSCL4.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:EFG04793.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002357}.
FT DOMAIN 799..874
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 88341 MW; 98EC6E8EBFAF0BAB CRC64;
MTSTVLTSDE SQGPTGTPGP TGIPGFRGVP GFSGSGLPPF DARSIHELVA EQAERAPDAP
AVSCGGQTLS YRQLVDRADR LARRLRDAGL RPEEVVGVLV RRSPELVVAL LAVLTAGGAY
LGLDPEDPPA RHELLLGDAG VGMVITEEAL RERVPDGVAA VGEEGPVPVV RPVRASPAPG
PGPDRLAYVS YTSGSTGEPK GVAVPHRAVD RLVRGADWME VRPGDVFFHI APVAFDASTL
EIWAPLVNGC RLAVFPPGTI ALAEVARTVR AEGVTVLLLT TGLFHRMAGS HPEAFAGVRH
VLTGGDVASP SHVERLLTLH PGLVYTNGYG PTENTTYTTC WTSDTLTNRE RVPIGGPISG
TRIAVLDSEL RPVPAGECGE LYAAGAGLAR GYLNRPGATA ERFLPDPSGT EPGARMYRTG
DLVRWTPDGT LEFVGRADQQ VKVQGYRAEP QAVEAALERL PGVRHAAVLP QPDPAGGTRL
LAYVVPDGVE LAAAGGATGG GVPAGAGGGA VGTDLSADAG GGAADVDVRD GAPGGGTGGG
VSVGARGGAA GAGVPGVSAP GGASGTVLPD GAGGGAADGD VPDGAPGEAT GGGVPAAEGG
AAGAGVPGAS APGGAVGTVL PDGALGRAGG GGVPGGARGG AAGAGVPGDV RGRATGGDVS
GDARGGGTGT DLPDGARERT VGRDLSADAG GTAAAGVLLA GTGSVAAQER TAAPGGATGT
GTDLPGGGPR GGTDVMSSDV LGLGGRLRRE LRAELPAYLI PWAILVRSEL PLNRNGKVDR
RALPGATRVP RNVPNAFTAP RTPTELRLAE LWGELLGVEP VGTDDDFFDL GGHSLLATEL
LAAVEREFGT AVPAQTLYLS PTVAELATAL DTRLHAAAEA AAEGSTR
//
