ID D5SSU7_PLAL2 Unreviewed; 1425 AA.
AC D5SSU7;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Plim_3080 {ECO:0000313|EMBL:ADG68898.1};
OS Planctopirus limnophila (strain ATCC 43296 / DSM 3776 / IFAM 1008 / Mu 290)
OS (Planctomyces limnophilus).
OC Bacteria; Planctomycetota; Planctomycetia; Planctomycetales;
OC Planctomycetaceae; Planctopirus.
OX NCBI_TaxID=521674 {ECO:0000313|EMBL:ADG68898.1, ECO:0000313|Proteomes:UP000002220};
RN [1] {ECO:0000313|EMBL:ADG68898.1, ECO:0000313|Proteomes:UP000002220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43296 / DSM 3776 / IFAM 1008 / 290
RC {ECO:0000313|Proteomes:UP000002220};
RX PubMed=21304691; DOI=10.4056/sigs.1052813;
RA Labutti K., Sikorski J., Schneider S., Nolan M., Lucas S.,
RA Glavina Del Rio T., Tice H., Cheng J.F., Goodwin L., Pitluck S.,
RA Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Tindall B.J., Rohde M., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Planctomyces limnophilus type strain (Mu
RT 290).";
RL Stand. Genomic Sci. 3:47-56(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP001744; ADG68898.1; -; Genomic_DNA.
DR RefSeq; WP_013111329.1; NC_014148.1.
DR STRING; 521674.Plim_3080; -.
DR REBASE; 69566; PliMORF3080P.
DR KEGG; plm:Plim_3080; -.
DR eggNOG; COG0827; Bacteria.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_252803_0_0_0; -.
DR OrthoDB; 249114at2; -.
DR Proteomes; UP000002220; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033455; BREX_6_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002220};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 323..402
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 559..644
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT REGION 672..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1393..1425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1425 AA; 160912 MW; 49736744E5229F07 CRC64;
MTMTPDAKTK LSKTIRALRE RLLTELNEAV DREYKFTLKN PKLDTKTKIK RQRLEDWLAE
QVRTQTGKVK RTKEVFRSDA EKQAAYTLLN RLVLLRILEA VGLRKPKVVT GGWNSQGYKD
FRELAQALVQ SDDGEGYPFL LQLIFEDLAI DLPGLYGSAG VADLIPVPSP TIRAVVEALD
DEALETCWTD DMTLGWVYQY WNDPEREALD AKINGGGKIE PHEIASKTQM FTERYMVDWL
LQNSLGPMWL AMCQKHGWTP GVVADGTLDR LEQRRSEWRA KRDAGEVALT DLMPLETDAE
RRWAYYVPQP IPEDAVDHAP PSLRDVKILD PAVGSGHFLV VAFDLLFALY KEEAKHRGQQ
AGEQWTDQAI VERILEHNLH GIDLDPRAVQ IAAAALWLKA QLVAPSAQIK QLNLVASNLG
ISRLADNDPS LVELRRAIEA ETGIPGKLTM QIVDALKGAD HLGSLLKIDQ AITEAMHSFE
KSLGMKDKVD RVLFGPELGS EIVIQSGGVD RAATEAGILS ALENFLSRHT SSEELGLRLA
GEQLAAGVRF VRLVKEGAYD LVVANPPYQG TSKMADVKYV ATHYKLAKAD LFAAFLLRGL
QLVREHGVSA MLTMRNWMFI KQYSDLRQHL LQTYDLRALG DFDRGAFEEI LDEVVAVAAA
CFARAPHRSE SVAQCPTPRE DRSRDNERTK RKRAATLCQV GRHTFDPAAL KVVPEWPLVY
WWDRAFLKAY SEVGTVGANS PARKGVCTSN NGWFIRRPWE ISVNRIRHPR SVDPTCHWAP
YVMGAAGKAW IEPVSFALEW SRHGLMVKVL NDYIYSSYSR TIQNQHLYFR KGVAFTTIGS
AFTGRSFRVP SIFDTTGCSV FGADIANTTA LFNSSKARSV LTSLNPTIHF TNGDVNRLPL
FPIENADDVF SLVETAFTNH ESHREPSVEF KRPGPSPWRQ AQEWAQLAVD RPEGAPLPEY
IEELDPEPPT DHLSFALGVA LGRFGAGGEG ILDPTKDDLS KALPAGILFL DGALGDDDRR
DSLGHHAAQI IHDNWSEYGP QIDKRRSLRD WLREKFFPDV HKGMYENRPI HWPLSSGKKT
FVAWVTIHRW NDQTLRVLLA DHLEPALKRL DGEITDLTAA RNSADRKQAR GAEDRYADVK
AWRDELAEFI HHVQECAERG PEPPDAKKPE REVDARYIPD LDDGVMINSA ALWPLLDPQW
KDPKKWWKEL VAAQGKKDYD WSHLAMRYWP TRVDEKCQKD PSLGVAHGCF WKYHPARAWA
WELRLQDEIG PEFEIKEASY RGDGGDSEHR INYLHKEPTE ALAAIEKEVL RRKRKQKQPQ
SELTILEPIL WSIVPDECWE LELRLTEKQQ VEFRLLAPDE PECRARFEQA HPDRVKSRCA
LVSKLSPPDL YVDLEDEDEA ASADAEDLDT EDADAIDANT GEVEA
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