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Database: UniProt
Entry: D5U0L7_THEAM
LinkDB: D5U0L7_THEAM
Original site: D5U0L7_THEAM 
ID   D5U0L7_THEAM            Unreviewed;       276 AA.
AC   D5U0L7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=2-oxoacid oxidoreductase (ferredoxin) {ECO:0000256|ARBA:ARBA00012691};
DE            EC=1.2.7.11 {ECO:0000256|ARBA:ARBA00012691};
GN   OrderedLocusNames=Tagg_0392 {ECO:0000313|EMBL:ADG90667.1};
OS   Thermosphaera aggregans (strain DSM 11486 / M11TL).
OC   Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Thermosphaera.
OX   NCBI_TaxID=633148 {ECO:0000313|EMBL:ADG90667.1, ECO:0000313|Proteomes:UP000002376};
RN   [1] {ECO:0000313|EMBL:ADG90667.1, ECO:0000313|Proteomes:UP000002376}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11486 / M11TL {ECO:0000313|Proteomes:UP000002376};
RX   PubMed=21304709;
RA   Spring S., Rachel R., Lapidus A., Davenport K., Tice H., Copeland A.,
RA   Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA   Detter J.C., Tapia R., Han C., Heimerl T., Weikl F., Brambilla E.,
RA   Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Thermosphaera aggregans type strain (M11TL).";
RL   Stand. Genomic Sci. 2:245-259(2010).
RN   [2] {ECO:0000313|Proteomes:UP000002376}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11486 / M11TL {ECO:0000313|Proteomes:UP000002376};
RX   DOI=10.4056/sigs.821804;
RA   Spring S., Rachel R., Lapidus A., Davenport K., Tice H., Copeland A.,
RA   Cheng J.-F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.-J., Jeffries C.C., Brettin T.,
RA   Detter J.C., Tapia R., Han C., Heimerl T., Weikl F., Brambilla E.,
RA   Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.-P.;
RT   "Complete genome sequence of Thermosphaera aggregans type strain
RT   (M11TLT).";
RL   Stand. Genomic Sci. 2:245-259(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 11486;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Spring S., Lapidus A., Munk C., Schroeder M., Glavina Del Rio T., Tice H.,
RA   Copeland A., Cheng J.-F., Lucas S., Chen F., Nolan M., Bruce D.,
RA   Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA   Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.-J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Tapia R., Han C., Chain P.,
RA   Heimerl T., Weik F., Goker M., Rachel R., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.-P.;
RT   "Complete genome sequence of Thermosphaera aggregans type strain (M11TL).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] =
CC         an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:42316, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737,
CC         ChEBI:CHEBI:33738, ChEBI:CHEBI:35179, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342; EC=1.2.7.11;
CC         Evidence={ECO:0000256|ARBA:ARBA00000005};
CC   -!- SUBUNIT: Heterodimer composed of an alpha and a beta subunit.
CC       {ECO:0000256|ARBA:ARBA00011631}.
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DR   EMBL; CP001939; ADG90667.1; -; Genomic_DNA.
DR   RefSeq; WP_013129260.1; NC_014160.1.
DR   AlphaFoldDB; D5U0L7; -.
DR   STRING; 633148.Tagg_0392; -.
DR   GeneID; 9165405; -.
DR   KEGG; tag:Tagg_0392; -.
DR   eggNOG; arCOG01599; Archaea.
DR   HOGENOM; CLU_048564_2_0_2; -.
DR   OMA; TCNSGWK; -.
DR   OrthoDB; 30755at2157; -.
DR   Proteomes; UP000002376; Chromosome.
DR   GO; GO:0018491; F:2-oxobutyrate synthase activity; IEA:UniProt.
DR   GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProt.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR48084; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ADG90667.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002376}.
FT   DOMAIN          67..207
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   276 AA;  30197 MW;  C23488C10A8C9818 CRC64;
     MALTIKTHPL DRHLRTDRIP TLYCPGCGLG IGLGAMLRGL QKRIDEGSIS PDSVVWVGGI
     GCSARLSFYV NYDSAHVLHG RAIPFAVGVK LANPELTVIV VGGDGDIAGI GGNHLLHAAR
     RNIDIITVMF TNFVYAMTGG QVAPTTPLGV RTTTTPHGNP EPPLDVVKVV SSLNANYVAR
     ASITTPHYIE QYFYKALGMR GFRFIEVVST CPEVYGRHIG LRDPVEMYNE LKKRVIYKPR
     PTLEEAAINW EKGIVIGEYI VRDNPGFIDF LRGGNK
//
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