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Database: UniProt
Entry: D5UF34_CELFN
LinkDB: D5UF34_CELFN
Original site: D5UF34_CELFN 
ID   D5UF34_CELFN            Unreviewed;       534 AA.
AC   D5UF34;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   25-OCT-2017, entry version 57.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Cfla_0001 {ECO:0000313|EMBL:ADG72921.1};
OS   Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073 / NRS
OS   134).
OC   Bacteria; Actinobacteria; Micrococcales; Cellulomonadaceae;
OC   Cellulomonas.
OX   NCBI_TaxID=446466 {ECO:0000313|EMBL:ADG72921.1, ECO:0000313|Proteomes:UP000000849};
RN   [1] {ECO:0000313|EMBL:ADG72921.1, ECO:0000313|Proteomes:UP000000849}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134
RC   {ECO:0000313|Proteomes:UP000000849};
RX   PubMed=21304688;
RA   Abt B., Foster B., Lapidus A., Clum A., Sun H., Pukall R., Lucas S.,
RA   Glavina Del Rio T., Nolan M., Tice H., Cheng J.F., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G., Pati A.,
RA   Goodwin L., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Rohde M., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Cellulomonas flavigena type strain
RT   (134).";
RL   Stand. Genomic Sci. 3:15-25(2010).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001964; ADG72921.1; -; Genomic_DNA.
DR   RefSeq; WP_013115255.1; NC_014151.1.
DR   ProteinModelPortal; D5UF34; -.
DR   STRING; 446466.Cfla_0001; -.
DR   EnsemblBacteria; ADG72921; ADG72921; Cfla_0001.
DR   KEGG; cfl:Cfla_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000849; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000849};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000849}.
FT   DOMAIN      226    354       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      438    507       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     234    241       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   534 AA;  59161 MW;  2E5C154DAD80F710 CRC64;
     MSQDEEPTRV WGHVVTSLEA SPDITPRQLA FVRLAHPLGL LDGTMLLAVG NDLTKEYLET
     RVRAEVTQAL TEALGREARF AITVDAEVAD DVPPALRVVP PAPSAPAGPS YDSPAYDGNA
     YEPPGYERSA EQRPDLALVT SHPGFLRDQG ADEDAALVTP AEQPVEARPS LRAVDGSSYD
     APAPRRGLSE PARLNPKYRF ETFVIGSSNR FAHAAAVAVA EAPAKAYNPL FIYGDSGLGK
     THLLHAIGHY AQNLYPTVRV RYVNSEEFTN DFINSIGEGK AGAFQRRYRE VDVLLIDDIQ
     FLQGKEQTME EFFHTFNTLH NASKQVVITS DVPPKQLNGF EDRMRSRFEW GLITDVQPPD
     LETRIAILRK KAASERLQAP DDVLEYIASR ISTNIRELEG ALIRVTAFAN LNRQLVDVSL
     AEIVLKDLIS DDQTQEITAT TVIGQTAAYF GLSIEDLCGS SRSRVLVTAR QIAMYLCREL
     TDLSLPKIGQ AFGGRDHTTV MHANRKIREL MAERRSIYNQ VTELTNRIKQ QHRG
//
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