ID   D5VRL0_METIM            Unreviewed;       304 AA.
AC   D5VRL0;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Methionine synthase vitamin-B12 independent {ECO:0000313|EMBL:ADG13213.1};
GN   OrderedLocusNames=Metin_0543 {ECO:0000313|EMBL:ADG13213.1};
OS   Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=573063 {ECO:0000313|EMBL:ADG13213.1, ECO:0000313|Proteomes:UP000002061};
RN   [1] {ECO:0000313|EMBL:ADG13213.1, ECO:0000313|Proteomes:UP000002061}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11812 / JCM 15783 / ME {ECO:0000313|Proteomes:UP000002061};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Woyke T.;
RT   "Complete sequence of Methanocaldococcus infernus ME.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; CP002009; ADG13213.1; -; Genomic_DNA.
DR   RefSeq; WP_013099959.1; NC_014122.1.
DR   AlphaFoldDB; D5VRL0; -.
DR   STRING; 573063.Metin_0543; -.
DR   GeneID; 9131549; -.
DR   KEGG; mif:Metin_0543; -.
DR   eggNOG; arCOG01876; Archaea.
DR   HOGENOM; CLU_040013_3_2_2; -.
DR   OrthoDB; 17656at2157; -.
DR   Proteomes; UP000002061; Chromosome.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   CDD; cd03311; CIMS_C_terminal_like; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          1..302
FT                   /note="Cobalamin-independent methionine synthase MetE C-
FT                   terminal/archaeal"
FT                   /evidence="ECO:0000259|Pfam:PF01717"
SQ   SEQUENCE   304 AA;  34847 MW;  6997189A731256B7 CRC64;
     MKTTVVGSYP VVKKEREELI DKIKKIFGLY DEFEYSIEIA VRDQVTAGVE IISDGQVRGD
     MIEIFTKNLY GFEDKRVINR VEFIKPITLK DLIFAKRVAK KIDSKVEVKG IITGPCTIAY
     SVRDEFYSNK EELILDLARA LRKEVEHLVR ETNYIQIDEP ILSTGIVDFD IAKRAIDIIT
     KDLNVFFAMH VCGSIYNIID ELNEFNVSLL DHEFASNKKN LEVLDRIKKK VGFGCVNTKS
     KKVESVEEIK EIIKEGLEIL KNNEFLSNNL HENVYIDPDC GMRLLSRDVA FKKLKNMVLA
     AKSI
//