ID   D5WZP5_THIK1            Unreviewed;      1333 AA.
AC   D5WZP5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=ATP-dependent helicase HrpA {ECO:0000313|EMBL:ADG30461.1};
GN   OrderedLocusNames=Tint_1067 {ECO:0000313|EMBL:ADG30461.1};
OS   Thiomonas intermedia (strain K12) (Thiobacillus intermedius).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Thiomonas.
OX   NCBI_TaxID=75379 {ECO:0000313|EMBL:ADG30461.1};
RN   [1] {ECO:0000313|EMBL:ADG30461.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 {ECO:0000313|EMBL:ADG30461.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ovchinnikova G., Kerfeld C.A., Cannon G.C.,
RA   Heinhorst S., Woyke T.;
RT   "Complete sequence of Thiomonas intermedia K12.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002021; ADG30461.1; -; Genomic_DNA.
DR   STRING; 75379.Tint_1067; -.
DR   KEGG; tin:Tint_1067; -.
DR   eggNOG; COG1643; Bacteria.
DR   HOGENOM; CLU_001832_3_3_4; -.
DR   BioCyc; TINT75379:TINT_RS05335-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:ADG30461.1};
KW   Hydrolase {ECO:0000313|EMBL:ADG30461.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          46..204
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          275..443
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1013..1042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1333 AA;  148224 MW;  4420EC939945921A CRC64;
     MPESTAARLP RQRHAAAPRK PVAATPVGEV RFPEDLPVSL RREDIARALR EHQVVIVCGE
     TGSGKTTQLP KIALSIGRGL GAGGTGLIGH TQPRRLAAVS IARRIAQELG SELGAIAGYK
     VRFNDRLQPG ASIKLMTDGI LLAETQTDPL LRAYDTLIID EAHERSLNID VLLGYLKQLL
     PRRPDLKVIV TSATIDAQRF AEHFAESAPR PAPGRPKPGG APSGGSDGAQ PGAWGPSTLA
     PVIEVSGRLY PVEVRWRPFG IDKGDDRDQS AAICDAVDEL WRLGSGDILV FLPGEREIRE
     AEAALRKHHL DTKRVGVEIL PLYARLSQAE QDRVFASGGA RRIVLATNVA ETSLTVPGIR
     YVIDAGLARV KRYSYRNKVE MLQVEPISQA AAQQRAGRCG RVANGVCIRL YDEAEFAERP
     RFTTPEIQRS SLAAVILRMK ALGLDSIEQF PFIEPPPGKA IADGYQLLTE LGAVDDRNAL
     TPLGRELARL PLDPRIGRMI LEARNREALT EVLIIAAALS VQDPRERPAE AQQAADEAHR
     KFSDERSEFL GWLKLWAHYH AAIAHKKSQR KLWGELRGQY LSPLRLREWH DVHSQLHTLV
     AEQGWRLNTA EATFEQIHCA LLSGLLGNVG YKGDDDAQYL GARGIRFAIH PSSPLGRKAG
     RWIMAAELVE TTRLYARGVA RIEPLWLERV GAHLLKTSLL DPHWEKKPAQ VTAFERATLY
     GLVVYNQRRV DFGRFDPKQA REIFLREALV AGEWDCRWPF FQHNQALIAD IERLEHKARR
     LDVLVDEELI YAFYDQQVPD EVHGGASFDR WYRDAVRAKP KLLFLQRDEL MRHEAAGITT
     ETFPNRLKLG ALELQLDYTF DPGGARDGVT VQAPLAALNQ IPAQRLQWLV PGLLKEKILA
     LLKSLPQRPR SRLVPLPQTA EAFAAQLTTA ERFGQGDLLD ALREQVREHT GLALQRTDFK
     LETLGPHLFF NVQVIDAHGR RIDVGRDIDK LRADHGQASR SAFAELAKLR TGLSPQKDAK
     APSEAPAPPR AAAGAAAAAP SEAPIDVPTD ALQGLTDWTF DALPELLELR RGAHTLIGFP
     ALVDKGAAVD VEVFDTAEEA ARLHRSGLRR LFALQLRDQI KHAEKNLPGF QQAAMQFMSL
     GTAELLRAQI VDAALDRAFL AEPLPADKSA FAQRLSEGKP RFQLLAAEMA RLAAQILDEY
     AQVQKKLAAF KNQPALHADI RAQLQALLPP RFIAETPPAQ IAHFPRYLQA IGRRLDKFRA
     DPARDAQLST QLAPWLTRWQ REAASYHGHL PPRLQELRWL LEELRVSLFA QELRTPMPVS
     LKRLEKVWAQ WQG
//