ID D5X0A2_THIK1 Unreviewed; 512 AA.
AC D5X0A2;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Flagellar biosynthesis protein FlhF {ECO:0000256|ARBA:ARBA00014919};
DE AltName: Full=Flagella-associated GTP-binding protein {ECO:0000256|ARBA:ARBA00030866};
GN OrderedLocusNames=Tint_1158 {ECO:0000313|EMBL:ADG30548.1};
OS Thiomonas intermedia (strain K12) (Thiobacillus intermedius).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Thiomonas.
OX NCBI_TaxID=75379 {ECO:0000313|EMBL:ADG30548.1};
RN [1] {ECO:0000313|EMBL:ADG30548.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 {ECO:0000313|EMBL:ADG30548.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ovchinnikova G., Kerfeld C.A., Cannon G.C.,
RA Heinhorst S., Woyke T.;
RT "Complete sequence of Thiomonas intermedia K12.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for flagellar biosynthesis. May be involved in
CC translocation of the flagellum. {ECO:0000256|ARBA:ARBA00025337}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family.
CC {ECO:0000256|ARBA:ARBA00008531}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002021; ADG30548.1; -; Genomic_DNA.
DR AlphaFoldDB; D5X0A2; -.
DR STRING; 75379.Tint_1158; -.
DR KEGG; tin:Tint_1158; -.
DR eggNOG; COG1419; Bacteria.
DR HOGENOM; CLU_009301_11_5_4; -.
DR BioCyc; TINT75379:TINT_RS05795-MONOMER; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd17873; FlhF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR020006; FlhF.
DR InterPro; IPR047040; FlhF__GTPase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR NCBIfam; TIGR03499; FlhF; 1.
DR PANTHER; PTHR43134:SF3; FLAGELLAR BIOSYNTHESIS PROTEIN FLHF; 1.
DR PANTHER; PTHR43134; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF00448; SRP54; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|ARBA:ARBA00022795};
KW Bacterial flagellum protein export {ECO:0000256|ARBA:ARBA00023225};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000313|EMBL:ADG30548.1};
KW Cilium {ECO:0000313|EMBL:ADG30548.1};
KW Flagellum {ECO:0000313|EMBL:ADG30548.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 293..445
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 294..485
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|SMART:SM00962"
FT REGION 51..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 53654 MW; 193910FFF333D3A5 CRC64;
MKIKRYTGTN TREVLTRIRN DLGADAVILS NREIVGGVEL MAAVDFDASR FPSEEPGEGG
AGTKAAVQTP PHPSPPHEWG GSTLRVASEN KAVETAKASP PRTELSSPTR GGGWEGHPKD
AQGAVFTSPT RGGGWEGEGS APQKPADDLP LPAVARVAAP TAPTTAPRAA LQAAPITLEQ
KDAASLATAH TGAAADPAIP AHRSMRDPAA ATAPKDELGA MRHELQDLRQ WMQLQMTSLA
DAGPLTPVGE QLQALGFSTA RARQLGSQAL NLRGALAAYL GKGLQVAADP VSAAGIYALV
GPTGAGKTTT IAKLAARLVL RHGTAAVALI TTDTYRIGGV EQLKIYGRIL GVPVAVARDG
EELQQHLRDF ADRRYVLIDS IGLSPRDARM AEQMQWLQAL GDSVTRLLVV GAGLAPSAYA
ELWSLYRRLP VAAAILTKLD ESPSFGAALQ WLVEGSVPLW FYTDGQRVPE DLHVPSLAKI
TALLEHDPVT RFDSAPAPLA AAAVGAITAR TA
//
