ID D5XDZ1_THEPJ Unreviewed; 1349 AA.
AC D5XDZ1;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ADG81862.1};
GN OrderedLocusNames=TherJR_0997 {ECO:0000313|EMBL:ADG81862.1};
OS Thermincola potens (strain JR).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Thermincolaceae;
OC Thermincola.
OX NCBI_TaxID=635013 {ECO:0000313|EMBL:ADG81862.1, ECO:0000313|Proteomes:UP000002377};
RN [1] {ECO:0000313|EMBL:ADG81862.1, ECO:0000313|Proteomes:UP000002377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JR {ECO:0000313|EMBL:ADG81862.1,
RC ECO:0000313|Proteomes:UP000002377};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Hazen T.C., Woyke T.;
RT "Complete sequence of Thermincola sp. JR.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP002028; ADG81862.1; -; Genomic_DNA.
DR STRING; 635013.TherJR_0997; -.
DR KEGG; tjr:TherJR_0997; -.
DR eggNOG; COG0395; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR eggNOG; COG5002; Bacteria.
DR HOGENOM; CLU_000445_70_44_9; -.
DR Proteomes; UP000002377; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 4.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002377};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 614..670
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 789..862
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 867..919
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 951..1084
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 1093..1347
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT COILED 530..557
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1349 AA; 151972 MW; EA3F04DC44849802 CRC64;
MLIGRKLGIS SVRSAIFLAI LIMLGIAGNV GGFPLFPGVN LLFGSIAVLL VIGLYGVFWG
VVAATVSYGF AFFWLREFCP LIIGILEAVF VGIHFRRKNE NLVLADGLFW FFLGLPLGWL
VNYFLLHLNL DEILVVTLKF GVNGIFNALV ASLILNHLPL SRWVFNSEEK GTVSFYQTVF
NLLMAFILIP ALIFTAVNNN RQQRQFTAGT KIHIIGEAKE IVAHLITWRH EHQHALNSLG
KIALQSNMQP TKELQKATEQ IKDSFTYFDR VHVDNIEATA ITFAPYRENG KLSLGTNFAD
RQHYKDMRAT LKPVISDVLL ARVGNAKPVV IMGVPIVEKD KLRGFVAGAL NLGYISDLLI
TTRHSDEMDI TLLDRNNKVI ASTRPALRPM QRYKPKLAEK NLPANNVYHW LPPDDGKLTE
LARWQNSCYV YESSVAPDIP WKLAIEIPFA PYLKEMLHNT TDYLAGMLGF TLVAFLLGSL
LSKHLTGPLA KLASVTTDLP CRISNREEIK WPYSPFTEMN SLVVNFRSMA GKLQQNFLEL
QQARMKAEEE KNKIEAIVAG IGDGISIQDT NYRVIFQNRI QRELMGEAVG QYCYQAYEGR
DQVCPGCPVA VSLQEGTIQT VERCPELKKG SLYIEVTSAP LKDAAGKITG AIEVVRDITE
RKKTEELLRQ QSAAMRASMD GMAILNTNGE YIYMNEAHAR IYGYANPAQL IGKTWHILYD
EEERDRFEKE VLPALYKQGY IRTEAVGRKA DGSLFPQEVS LTLIEGGGTV CVVRDITERK
QAEQAIWEEK ERAQVTLHSI GDAVITTDGQ GIITYLNPVA EVLTGWTNDE ACGRPLLEVF
NIINETTGQV VENPVTKCLR EGNIVGLANH TVLIHRSGRR YAIEDSAAPI KNREGEIIGV
VLVFHDVSEK RNMIEQLTHQ AYHDPLTDIP NRVLFNDRLN VALAHAKRNN EMLAVMFLDL
DRFKLVNDML GHSIGDRLLQ EVAKKLSICL RKGDTIARLG GDEFTLLLPQ IKSEKEAAKI
AQKILKAFQK PVTLSGHEFY ITASIGVALY PSDGEKAEIL MKNADTAMYR AKEQGRNTYQ
LYTPAMNKKI VERMAMENSL RHALERRELV VYYQPLVCIR TGRITGMEAL IRWRHKELGL
VPPAEFIPLA EETGLIIPIG EWVLRTACAQ NKAWQDAGYM PVRVTVNLSA YQFQHQNLVN
TVAKTLKQTG LHPQYLELEI TESIAMQDVD YTVDVLRKLR EMGVQIAIDD FGTGYSSLRY
LKRFPINTLK IDRSFVRDIA CDPNDAAIVS TIIVLCRNMN LKVIAEGVET EEQLNFLKNQ
HCYEMQGYFF SQPVPEKEFE ELLKRYNMP
//
