ID   D6AN54_STRFL            Unreviewed;       444 AA.
AC   D6AN54;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=SSGG_00847 {ECO:0000313|EMBL:EFE73481.2};
OS   Streptomyces filamentosus NRRL 15998.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=457431 {ECO:0000313|EMBL:EFE73481.2, ECO:0000313|Proteomes:UP000003986};
RN   [1] {ECO:0000313|Proteomes:UP000003986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 15998 {ECO:0000313|Proteomes:UP000003986};
RA   Molnar K.;
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000003986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 15998 {ECO:0000313|Proteomes:UP000003986};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Ward D., Young S., Kodira C.D., Zeng Q., Koehrsen M.,
RA   Godfrey P., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I.,
RA   Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D.,
RA   Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S.N., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland B.L.C., Ilzarbe M.,
RA   Galagan J., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces roseosporus strain NRRL 15998.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS999644; EFE73481.2; -; Genomic_DNA.
DR   AlphaFoldDB; D6AN54; -.
DR   Proteomes; UP000003986; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR026367; FxsC_C.
DR   InterPro; IPR047603; FxsC_N.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   NCBIfam; TIGR04276; FxsC_Cterm; 1.
DR   NCBIfam; NF040588; FxsC_Nterm; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
FT   DOMAIN          20..181
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          407..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  49353 MW;  8230743BB3E32FB1 CRC64;
     MLIQDGGRVH ASTQQRAVGH RPYFFLSYAH TPGYGAGTDP DMWVERLFQD LCGHVMAMTD
     LPAGAPAGFM DREIRSGEGW SERLGDVLAT CRVFVPLFSP RYFASEMCGK EWYAFEQRAI
     HHRARSNQPA EAIVPALWVP VPPSQLPGSA ERLQFNHRDF GERYVSDGLY GLIKLRLFAE
     EYERAVYELA KRIVSVADSV RIDTGRPVDY RLAPSAFGSP SSGVGAPRPM QITIAAPTRH
     DLPEGRNSDH YGDHPQDWNP YYPASARPLA YVAEELVRSL NYQAVITSFD EDRHDGKAPP
     STPEILLVDR WALRDEDHCR RLAAFDAENR PWVTMVVPWS RDDHQSRAAE TELTEKLEAV
     MPVKMGQGRA LCRAAAKGVP TMEAFGQLLP QVVEVAAQQY LKHAKAYPPG SGGGSGERTR
     LTGPMGNTSY IPDPHDPATE AEDL
//