ID D6BCS0_9FUSO Unreviewed; 1075 AA.
AC D6BCS0;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=PSAG_00002 {ECO:0000313|EMBL:EFD79967.2};
OS Fusobacterium animalis D11.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=556264 {ECO:0000313|EMBL:EFD79967.2, ECO:0000313|Proteomes:UP000004650};
RN [1] {ECO:0000313|Proteomes:UP000004650}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D11 {ECO:0000313|Proteomes:UP000004650};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Allen-Vercoe E., Strauss J., Sibley C., White A.,
RA Ambrose C., Lander E., Nusbaum C., Galagan J., Birren B.;
RT "The Genome Sequence of Shigella sp. D9.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EFD79967.2, ECO:0000313|Proteomes:UP000004650}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D11 {ECO:0000313|EMBL:EFD79967.2,
RC ECO:0000313|Proteomes:UP000004650};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Kostic A., Garrett W.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusobacterium nucleatum subsp. animalis D11.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFD79967.2}.
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DR EMBL; ACDS02000152; EFD79967.2; -; Genomic_DNA.
DR AlphaFoldDB; D6BCS0; -.
DR Proteomes; UP000004650; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..476
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 477..746
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 11..18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1075 AA; 127673 MW; E4EF6945E4A9DCCA CRC64;
MNKIKNLVLK ASAGTGKTYR LSLEYIAALC KKGDIEPIDY KNILVMTFTR KATAEIKEGI
LNKLSEFMEI YEISKKSEFS VIEAISNSKL IDDKKKSNYF NLIDSIKNIE PNLLIDNNFL
ENLSKVNKEI IKNKEKLKIY TIDAFFNIIF KNIVTNLMKI RSYTMLDEED NFSYYKKVLE
NIFNNEKLFN DFKNFFTENS EKNIDNYISI IQRLISSRWK YILSLNDNPK PTKKEKFNIS
KSSIEILKEI FSYIENDCKK DLDDVLKNDY KKYIGKTEET QKEFLFKNFK LLFKDGTTGL
IYNGNKLKKA SDAEHKEYIN ARHKELRKVL SKEIFNEVLI PYEEKIFELS SEIYNLYDSF
KIRDKKFTFS DIAIYTYMAI FNKNNTLRDE NGLTDIFFET LDMNIEAIFI DEFQDTSILQ
WKILYEFTKK AKTVICVGDE KQSIYGWRDG EKRLFENLET ILEAKEDSLG KSYRSDRNIV
SYCNQFFKAI EKIEDWKFPT SEVNSKNDGY VKAICIKDLQ DEIEDEEQKK KVNINTVLLQ
ELKKFEPYDN VAIIARTNAE LSEIANLLED EKIPYILNNE KNISEYSGIF ECFELLKYLV
YENELALFNF ISSPLSNFGT DEIEILLKNK EELFSYINFS QDNDFINSLE NKKIIRFLEK
IVFLKKNYRD FTVQDLIFEI IKKFQFIDYF NKDNEVKNIY DFYLLTNYYS SILELLNDYK
ENKLILSDTN SEKKGVELVT IHKSKGLEFK TTFVIKNGKK SKTDDIDFLF EMNDKYDETV
FSLFCKKGYK SILETCFEER IENYDKKIKE EEINNFYVAL TRPKNNLIVI YEDRLFEEKS
LKEFSSEELK GINLEDISFE KSVINDFFDC KIGEFSSSEK NSNSDDTAKE NLESDLFNSQ
PYFISSIYEN EKETEKIEIN DSKFLLETEE KRMIGILVHY FFENLKYGTD EEVEFSKTLC
YKKYLSYFGE EKLNKIFSKE NIEMFLTKDK EIFSKKWDYI YSEYVLYDYE EKKEYRIDRL
MIKDNGDGTG EIYIVDFKTG GKDESQLKTY KEVLKKNFEE LQNYNIRTKF LEFDI
//
