ID D6CJT7_9BACT Unreviewed; 179 AA.
AC D6CJT7;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=folA {ECO:0000313|EMBL:CAX68900.1};
GN ORFNames=JG1_0140 {ECO:0000313|EMBL:CAX68900.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:CAX68900.1};
RN [1] {ECO:0000313|EMBL:CAX68900.1}
RP NUCLEOTIDE SEQUENCE.
RA Gloeckner J., Kube M., Shrestha P.M., Weber M., Gloeckner F.O.,
RA Reinhard R., Liesack W.;
RT "Phylogenetic diversity and metagenomics of candidate division OP3.";
RL Environ. Microbiol. 12:1218-1229(2010).
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|RuleBase:RU004474}.
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DR EMBL; FP245538; CAX68900.1; -; Genomic_DNA.
DR AlphaFoldDB; D6CJT7; -.
DR UniPathway; UPA00077; UER00158.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAX68900.1}.
FT DOMAIN 6..177
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 179 AA; 20454 MW; 826E2C593A0914D3 CRC64;
MSSIFGFTVI VAMDENRGIG RANELPWHLP EDLKHFREVT CQVENRDNQN AVIMGRKTWE
SLPQAYRPLP HRKNIVLSRK HLNSPPEVMA FSDFDAAIRS LSAMDRIEKI FVIGGGQVFE
TAIRHSQCQE ILVTEIQDSF KCDVFFPDIS SRFGISNESV VFQSKTGLSY KFISFKPSR
//
