ID D6DD00_BIFLN Unreviewed; 772 AA.
AC D6DD00;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=BIL_07970 {ECO:0000313|EMBL:CBK70371.1};
OS Bifidobacterium longum subsp. longum F8.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=722911 {ECO:0000313|EMBL:CBK70371.1, ECO:0000313|Proteomes:UP000007063};
RN [1] {ECO:0000313|EMBL:CBK70371.1, ECO:0000313|Proteomes:UP000007063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F8 {ECO:0000313|EMBL:CBK70371.1,
RC ECO:0000313|Proteomes:UP000007063};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Bifidobacterium longum longum F8.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBK70371.1, ECO:0000313|Proteomes:UP000007063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F8 {ECO:0000313|EMBL:CBK70371.1,
RC ECO:0000313|Proteomes:UP000007063};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; FP929034; CBK70371.1; -; Genomic_DNA.
DR RefSeq; WP_008783099.1; NC_021008.1.
DR AlphaFoldDB; D6DD00; -.
DR KEGG; blg:BIL_07970; -.
DR PATRIC; fig|722911.3.peg.149; -.
DR HOGENOM; CLU_006146_4_1_11; -.
DR Proteomes; UP000007063; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd16928; HATPase_GyrB-like; 1.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR002288; DNA_gyrase_B_C.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF00986; DNA_gyraseB_C; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CBK70371.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 547..661
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 145..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 84669 MW; 1ECEA84B3F3F0169 CRC64;
MPKEEYGAKD LAVLEGLDAV RKRPGMYIGT TDSQGLMHCL WEIIDNSVDE ALAGFCNDIV
VTLHTDGSVE VADNGRGIPV DKEPKTGLSG VEVVLTKLHA GAKFGNSSYN AVGGLHGVGS
SVVNALSSRL DVEVDRDGKT HHMTFHQGHP GVYTDADPAN PSPDSPFKRT RKNRPTELEI
IGKVSPKTTG TRIRYWYDPE IFNKTAEFSY EQLIDRVRQT SFLVPGLKIT IIDENVPETA
ATDTVEATDD TTVEPAQDQA PALDVSSNDA ELFDDSAESQ SDDAESPAEE DFSLTAGDQV
VDGAFGEQPA HPRVVEFLHT GGVKDFVDFL SKGEPISDIW RIQGEGTYKE ETQAVGEGGE
LHAQEIERTC GVDIALRWVN GYDTTIMSFV NIVETPGGGT HVDGFMNAIT KQIRKAVEDN
ARKLKVNMKD SAMKVERDDI QAGLVAVVTA RVAEPQFQGQ TKDVLGTAQV KPIVTRLTDK
QFGEMITGSK RGYKEQSGRV LEKIVGEMHA RIQSRKAKEV TRRKNALESA SMPAKLSDCQ
PGNDDVAELF IVEGDSALGT AKAARNAGFQ ALLPIRGKIL NVQKASITQM LSNKECAAII
QVVGAGSGQS FDIEQSRYHK IIMMTDADVD GAHIRILLLT LFYRYMRPLI EHGYVYAAVP
PLHRIALTGS HKGEYIYTYS DDELAGKLAD LDKKHIGYND DIQRYKGLGE MDADQLADTT
MDPRTRMLRR IRMEDAAQAS EIFSLLMGDD VPPRKQFIVD NADDFDRSKI DT
//