ID D6IH19_ECOLX Unreviewed; 488 AA.
AC D6IH19;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Outer membrane efflux protein MdtP {ECO:0000313|EMBL:EFF03300.2};
GN ORFNames=ECDG_02500 {ECO:0000313|EMBL:EFF03300.2};
OS Escherichia coli B185.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=550676 {ECO:0000313|EMBL:EFF03300.2, ECO:0000313|Proteomes:UP000004669};
RN [1] {ECO:0000313|EMBL:EFF03300.2, ECO:0000313|Proteomes:UP000004669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B185 {ECO:0000313|EMBL:EFF03300.2,
RC ECO:0000313|Proteomes:UP000004669};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Escherichia coli B185.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could be involved in resistance to puromycin, acriflavine and
CC tetraphenylarsonium chloride. {ECO:0000256|ARBA:ARBA00037313}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004459, ECO:0000256|RuleBase:RU362097}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004459, ECO:0000256|RuleBase:RU362097}.
CC Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613, ECO:0000256|RuleBase:RU362097}.
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DR EMBL; GG749190; EFF03300.2; -; Genomic_DNA.
DR RefSeq; WP_000610585.1; NZ_GG749190.1.
DR AlphaFoldDB; D6IH19; -.
DR Proteomes; UP000004669; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR Gene3D; 2.20.200.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR003423; OMP_efflux.
DR InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR NCBIfam; TIGR01845; outer_NodT; 1.
DR PANTHER; PTHR30203:SF20; MULTIDRUG RESISTANCE OUTER MEMBRANE PROTEIN MDTP-RELATED; 1.
DR PANTHER; PTHR30203; OUTER MEMBRANE CATION EFFLUX PROTEIN; 1.
DR Pfam; PF02321; OEP; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|RuleBase:RU362097};
KW Membrane {ECO:0000256|RuleBase:RU362097};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139, ECO:0000256|RuleBase:RU362097};
KW Transmembrane {ECO:0000256|RuleBase:RU362097};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452,
KW ECO:0000256|RuleBase:RU362097}.
SQ SEQUENCE 488 AA; 53397 MW; 283121608C1B147C CRC64;
MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL ASSGWPQAQW
WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL DAGSQLQVAA LGMLNRQRVS
ANGFLSPYAM DAPALGMDGP YYTEATVGLF AGLDLDLWGV HRSAVAAAIG AHNAALAETA
AVELSLTTGV AQLYYSMQAS YQMLDLLEQT RDVIDYAVKA HQSKVAQGLE AQVPFHGARA
QILAVDKQIA AVKGQITETR ESLRALIGAG ASDMPEIKPV ALPQVQTGIP ATLSYELLAR
RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDAI HLDTLFKKTS RQFNFIPGLK
LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV NGTRLQTLND EREMQAERVE
ATRFTQRAAE AAYQRGLTSR LQATEARLPV LAEEMSLLML DSRRVIQSIQ LMKSLGGGYQ
AAPVVEKK
//
