ID D6K0Z1_9ACTN Unreviewed; 416 AA.
AC D6K0Z1;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:EFF91106.2};
DE Flags: Fragment;
GN ORFNames=SSTG_01424 {ECO:0000313|EMBL:EFF91106.2};
OS Streptomyces sp. e14.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF91106.2, ECO:0000313|Proteomes:UP000004704};
RN [1] {ECO:0000313|EMBL:EFF91106.2, ECO:0000313|Proteomes:UP000004704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces sp. strain e14.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000849};
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DR EMBL; GG753626; EFF91106.2; -; Genomic_DNA.
DR RefSeq; WP_009188681.1; NZ_GG753626.1.
DR AlphaFoldDB; D6K0Z1; -.
DR STRING; 645465.SSTG_01424; -.
DR eggNOG; COG2072; Bacteria.
DR OrthoDB; 9778740at2; -.
DR Proteomes; UP000004704; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR48105; THIOREDOXIN REDUCTASE 1-RELATED-RELATED; 1.
DR Pfam; PF13738; Pyr_redox_3; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000004704}.
FT NON_TER 416
FT /evidence="ECO:0000313|EMBL:EFF91106.2"
SQ SEQUENCE 416 AA; 44497 MW; C8E255B4BE54CD33 CRC64;
MKYDLVVVGA GPYGLSIASH AAAAGLNLRV FGRPMASWRD HMPRGMLLKS EPWASNLSDP
AGRWRLDAYC AERGMAARHA EPMPVETFAA YGLWFARNAV PGVDERTVVR ISSGPGGFTV
VTEDGQAVQA RTVALAVGVM PFVEVPPVLR ALRPSLVTHS SDHSDLTRFR GMDVTVVGGG
QAALETAALL AEQGSRARVL ARAGQLRWND LPPVLERPWW QSVRSPHSGL GPGWRNWFYS
ERPNLFRRLP EPTRARIAAS ALGPAGAWWV RDRVERAVEL LPGHEIASAR AAGGGLRLET
VRLDGTVCTV ETEHVIAATG FRTSCDRFGM LAAELRGTLA ALPDGSPEVG HDFESSHPGL
FLAGLVTASG FGPAMRFVQG ATFTASALVR GVRRRLRTAP ATVMVPGPGG SRTAAP
//
