ID D6K5V4_9ACTN Unreviewed; 1325 AA.
AC D6K5V4;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=ATP-dependent helicase HrpA {ECO:0000313|EMBL:EFF91862.2};
GN ORFNames=SSTG_02181 {ECO:0000313|EMBL:EFF91862.2};
OS Streptomyces sp. e14.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF91862.2, ECO:0000313|Proteomes:UP000004704};
RN [1] {ECO:0000313|EMBL:EFF91862.2, ECO:0000313|Proteomes:UP000004704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces sp. strain e14.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG753626; EFF91862.2; -; Genomic_DNA.
DR RefSeq; WP_009189429.1; NZ_GG753626.1.
DR STRING; 645465.SSTG_02181; -.
DR eggNOG; COG1643; Bacteria.
DR OrthoDB; 9805617at2; -.
DR Proteomes; UP000004704; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd17989; DEXHc_HrpA; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EFF91862.2};
KW Hydrolase {ECO:0000313|EMBL:EFF91862.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000004704}.
FT DOMAIN 87..251
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 279..446
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1325 AA; 150579 MW; 1D5D4D2E65C5A6BD CRC64;
MSTHPAPALG ALASRLTELS LRDAHRLGRR LEGARKIRKP EARAAVLTEI EAEVAKAEER
MAARRSRVPA VSYPEQLPVS QKKDAIAAAI RDHQVVIVAG ETGSGKTTQI PKICMELGRG
VRGMIGHTQP RRIAARTVAE RVAEELDTPL GEAVGWKVRF TDQVDPEATF VKLMTDGILL
AEIQTDRELR AYDTIIIDEA HERSLNIDFL LGYLAQLLPK RPDLKVVITS ATIDPERFSR
HFGDAPIIEV SGRTYPVEVR YRPLLEEDSD DADRDQITAI TDAVEELMAE GPGDILVFLS
GEREIRDTAD ALNKKQYRFT EVLPLYARLS HAEQHRVFQQ HTGRRIVLAT NVAETSLTVP
GIKYVIDPGF ARISRYSHRT KVQRLPIEPI SQASANQRKG RCGRTSDGIC IRLYSEDDFL
ARPEFTDAEI LRTNLASVIL QMTAAGLGDI EKFPFIDPPD HRNIRDGVQL LQELGALDPA
QKDPRKRLTQ TGRKLAQLPV DPRLARMVLE ADRNGCAREV MVIAAALSIQ DPRERPADKQ
TQADQQHARF RDETSDFLAF LNLWRYVREQ QKERGSSSFR RMCKQEFLNF LRIREWQDIY
TQLRTVAKQM GIHLNEDDAP ADRVHVSLLA GLLSHIGMKD VKESKDSAPG ARRDGGRGEY
LGARNAKFAI FPGSALFKKP PRFVMSAELV ETSRLWARVN AKIEPEWVEP LAEHLLKRTY
SEPHWEKDQA AVMAYEKVTL YGVPIVAQRK VNYGRIDPEA SRELFIRNAL VEGDWRTHHK
FFADNRKLLS EVEELEHRAR RRDIVVDDET LFDFYDQRVP EHVVSGAHFD SWWKRKRQEQ
PDFLDFEREM LIRESAEAVT KADYPDSWRQ GNLKFRVTYQ FEPGADADGV TVHIPLQVLN
QVTDEGFDWQ IPGLREEVVT ELIRSLPKPI RRNYVPAPNF AKRFLDSAVP LQEPLTLTMA
RELKRMVGVP FEAEDFDWSK VPDHLKITFR IVDERRRKLA EDKDLEALKL RLRPKARKAL
SQAAAATAER TGGEALERTG LTDWTIGSLT RIFETRRAGQ PVKAYPALVD DGDTVSVRLF
DTEAEQAEAM WKGTRRLILR NIPVNPAKFA SEKLTNQQKL ALSANPHGSI QALFDDCAMA
AADRLIGEFG GPAWDEESYR KLYDKVRAEI VDLTVRTVGQ VQQVLAAWQA CERRLKAVRS
PALLPNLTDV RAQLDALVKP GFVTEAGIRR LPDLMRYLVA VDRRLQQMPT NVQRDITRME
KVHEMRDEYA WLLEQLPQGR PVPQQVRDIR WMIEELRVSY FAHALGTAYP VSDKRIVKAI
DAAAP
//
