ID D6K8T8_9ACTN Unreviewed; 269 AA.
AC D6K8T8;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Secreted hydrolase {ECO:0000313|EMBL:EFF90233.2};
GN ORFNames=SSTG_00551 {ECO:0000313|EMBL:EFF90233.2};
OS Streptomyces sp. e14.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF90233.2, ECO:0000313|Proteomes:UP000004704};
RN [1] {ECO:0000313|EMBL:EFF90233.2, ECO:0000313|Proteomes:UP000004704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces sp. strain e14.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG753626; EFF90233.2; -; Genomic_DNA.
DR RefSeq; WP_009187811.1; NZ_GG753626.1.
DR AlphaFoldDB; D6K8T8; -.
DR STRING; 645465.SSTG_00551; -.
DR eggNOG; COG2755; Bacteria.
DR OrthoDB; 5503950at2; -.
DR Proteomes; UP000004704; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR CDD; cd01823; SEST_like; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR037460; SEST-like.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR37981; LIPASE 2; 1.
DR PANTHER; PTHR37981:SF1; SGNH_HYDRO DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637460-2};
KW Hydrolase {ECO:0000313|EMBL:EFF90233.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000004704};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..269
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003086029"
FT DOMAIN 41..257
FT /note="SGNH hydrolase-type esterase"
FT /evidence="ECO:0000259|Pfam:PF13472"
FT ACT_SITE 45
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-1"
FT ACT_SITE 251
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-1"
FT DISULFID 62..87
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
FT DISULFID 128..136
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
FT DISULFID 186..232
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
SQ SEQUENCE 269 AA; 27663 MW; B332E740716CB277 CRC64;
MRRSRIAARV SSILIAVGLA LTGAASAQAS QQTAAAGGYV ALGDSYSSGV GAGSYISSSG
SCDRSTKAYP YLWNAAHAPS SFSFTACSGA KTDDVLASQL SPLNSATSLV SLTIGGNDAG
FADVMTTCVT SSDSTCISRI NTARAYVTST LPGKLDNLYS VIRGKAPSAR VVVIGYPRFY
KLGQTCLGLS DTKRSAINDA SDLLDATIAK AAANHGFVFG DVRTTFSGHE ICSGDSWLHS
VNWLDIGESY HPTASGQSGG YLPVLTNAA
//
