ID   D6KAQ1_9ACTN            Unreviewed;       409 AA.
AC   D6KAQ1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0000259|Pfam:PF00149};
GN   ORFNames=SSTG_02751 {ECO:0000313|EMBL:EFF92432.2};
OS   Streptomyces sp. e14.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF92432.2, ECO:0000313|Proteomes:UP000004704};
RN   [1] {ECO:0000313|EMBL:EFF92432.2, ECO:0000313|Proteomes:UP000004704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces sp. strain e14.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC       {ECO:0000256|RuleBase:RU362119}.
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DR   EMBL; GG753626; EFF92432.2; -; Genomic_DNA.
DR   RefSeq; WP_009189992.1; NZ_GG753626.1.
DR   AlphaFoldDB; D6KAQ1; -.
DR   STRING; 645465.SSTG_02751; -.
DR   eggNOG; COG0737; Bacteria.
DR   OrthoDB; 9803927at2; -.
DR   Proteomes; UP000004704; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR11575:SF48; 5' NUCLEOTIDASE, ECTO-LIKE; 1.
DR   PANTHER; PTHR11575; 5'-NUCLEOTIDASE-RELATED; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU362119};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004704}.
FT   DOMAIN          10..194
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
SQ   SEQUENCE   409 AA;  44207 MW;  2ADC753A842F610C CRC64;
     MTATRTLRQI VATTDVHSTL DRAAPFLTHL HVLRPTSLVV DCGDFFEGSG YYRLAHGAIE
     RKILLKLYDV LAPGNHGWPH HFEPDLHCLT VCANAVHADT GDTLFRRARV VEIDGRRVGV
     TAVIGRQAFD SIPVGQRAEH RVTDPVQALR ELMLAHHHEV DIWILLSHSG FDEDLKLAAA
     CPFLDVIFAG HCHSDQSGPA RVGDTLIVKG RELADGYAVA TPIGPGWGAG TTRFPDRKPA
     AVPAELSEAI KEIGRVGKEL ASGLGPVARA YRHQTPNRRG LLLDLATRLR SGLGVDAVIL
     NHTALRPVAL GDILTLGDLL AIEPFDNQLV HARIPEHFRQ DVHGLLTSLT EQAGLLVTSP
     DPLPDSITTV LTTHYLADNY LAGRSHAAGL LLSQALKHVL TAPADGGTR
//