ID D6LH04_9FUSO Unreviewed; 682 AA.
AC D6LH04;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HMPREF0400_01004 {ECO:0000313|EMBL:EFG27680.2};
OS Fusobacterium periodonticum 1_1_41FAA.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=469621 {ECO:0000313|EMBL:EFG27680.2, ECO:0000313|Proteomes:UP000003964};
RN [1] {ECO:0000313|EMBL:EFG27680.2, ECO:0000313|Proteomes:UP000003964}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1_1_41FAA {ECO:0000313|EMBL:EFG27680.2,
RC ECO:0000313|Proteomes:UP000003964};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S.K., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chapman S., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Strauss J.C.,
RA Ambrose C.E., Allen-Vercoe E., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusobacterium sp. 1_1_41FAA.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; GG770383; EFG27680.2; -; Genomic_DNA.
DR RefSeq; WP_008820968.1; NZ_GG770383.1.
DR AlphaFoldDB; D6LH04; -.
DR Proteomes; UP000003964; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF02384; N6_Mtase; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 357..491
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 500..612
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 682 AA; 77380 MW; BD44556D594EEA8B CRC64;
MVAKKEKSIE PNITDLVNGW LKSYNLDYKL EQESLNSEID KALDEYKSKS GGDGGNRPDA
KLLLQDEKLN YYPILIEYKG YKDKLVKFDG NGRVDNRTSK NEPNYKNINS YAVNGAIHYA
NAILHYTSYT DVIAIGVTGY KKPDETIEHS IGVYYVSKKN LGIGQEVDKY TDLSFLKKEN
FNNFIKKVNQ LSLTNEELEL LKEKREKEIN TSLTKLNNDI YANEKGLSET DRVYLVSASI
MATLGISGQV TPLEKSDLKS SLEEGSTDGE IIIRKIEAFL KRKNLPIKKQ ELIVRTLKNT
LLSDNINKPV NGESQLKRIF SKIVDDLGIY YKIGLTTDFT GKLFNEMYSW LGFTQDKLND
VVLTPSYVAN FLVKLARVNK DSYVWDFATG SAGLLVAAMN EMLIDAKDKI KSPQELEQKT
LKIKAEQLLG LEVLSNIYML AILNMILMGD GSSNILNKDS LRDFNGNYAF GEENKKFPAT
AFVLNPPYSA EGNGMIFVEK ALSLMEKGYA AIIIQHSAGS GKAKEYNKKI LEKNTLLASI
KMPLDLFIGK SSVQTYIYVF RIGEVHQKDE IVKFIDFSND GYTRSDRKKA SNNLKDTDRA
KERYQEMVDL VRFGKSKLNI FTEKEYYEGY IDPENGSDWN QSTPVDTKPT IEDFKKTVAD
YLAWEVSNLL KNTERENESL KK
//